{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:54:48Z","timestamp":1791190488615,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:\u2003<\/jats:bold> The study aimed to assess the possible association of polymorphisms in the autophagy gene <jats:italic>IRGM<\/jats:italic> (rs13361189 and rs4958847) with the risk of gastric cancer.<\/jats:p><jats:p><jats:bold>METHODS:\u2003<\/jats:bold> A total of 102 patients with gastric adenocarcinoma, 52 with chronic gastritis and 351 healthy controls were included in this study. <jats:italic>IRGM<\/jats:italic> allelic variants were genotyped by quantitative real\u2010time polymerase chain reaction. The association between polymorphisms and gastric cancer risk was estimated by odds ratios (OR) and 95% confidence interval (CI).<\/jats:p><jats:p><jats:bold>RESULTS:\u2003<\/jats:bold> A significant difference was found for rs4958847 A allele. Carriers of the A allele were protected against gastric cancer (OR\u2003=\u20030.58, 95% CI 0.35\u20130.97, <jats:italic>P<\/jats:italic>\u2003=\u20030.038). Moreover, the presence of this allele seems to play an important role in decreasing the risk for the intestinal type of gastric cancer (OR\u2003=\u20030.47, 95% CI 0.23\u20130.94, <jats:italic>P<\/jats:italic>\u2003=\u20030.03). In contrast, the rs13361189 <jats:italic>IRGM<\/jats:italic> polymorphism was not associated with susceptibility to gastric cancer. None of the targeted polymorphisms were associated with chronic gastritis.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2003<\/jats:bold>  <jats:italic>IRGM<\/jats:italic> rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type.<\/jats:p>","DOI":"10.1111\/j.1751-2980.2012.00602.x","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T15:37:13Z","timestamp":1334158633000},"page":"360-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>IRGM<\/i> gene polymorphisms and risk of gastric cancer"],"prefix":"10.1111","volume":"13","author":[{"given":"Florin","family":"BURADA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo 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