{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T16:26:12Z","timestamp":1747326372862},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to estimate the efficacy of flexible spectral imaging color enhancement (<jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>) on the detection of small intestinal diseases by capsule endoscopy (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six individuals without significant lesions and 18 patients with following diseases were selected: four tumors, five angioectasias, seven ulcerative diseases, one ulcerative lesion and tumor and one ulcerative lesion and angioectasia. Three endoscopists reviewed all <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> videos on standard and three types of <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> modes and compared their sensitivity and specificity for detection of small intestinal diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall sensitivity of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> was 94.4% at standard mode, 90.7% at <jats:styled-content style=\"fixed-case\">FICE <\/jats:styled-content>channel (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>h) 1, 87.0% at <jats:styled-content style=\"fixed-case\">FICE C<\/jats:styled-content>h 2 and 87.0% at <jats:styled-content style=\"fixed-case\">FICE C<\/jats:styled-content>h 3 and the overall specificity of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> was 66.7%, 55.6%, 77.8% and 66.7%, respectively, per patient. There was no significant difference between the standard and each <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> mode. In per\u2010lesion analysis, <jats:styled-content style=\"fixed-case\">FICE C<\/jats:styled-content>h 1 detected more angioectasias and ulcerative lesions than the standard mode (angioectasia, 25.7 <jats:italic>vs<\/jats:italic> 21.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.005; ulcerative lesions, 19.3 <jats:italic>vs<\/jats:italic> 14.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.06). However, <jats:styled-content style=\"fixed-case\">FICE C<\/jats:styled-content>h 1 missed more tumors than the standard mode (4.3 <jats:italic>vs<\/jats:italic> 10.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">FICE C<\/jats:styled-content>h 1 is better in detecting angioectasias and ulcerative lesions and worse in tumors or polyps than the standard mode, the patient\u2010based sensitivity and specificity of small intestinal diseases are not different between standard and each <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> mode. Further experiences with and improvement of <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1751-2980.2012.00641.x","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T09:31:09Z","timestamp":1346837469000},"page":"614-620","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of flexible spectral imaging color enhancement on the detection of small intestinal diseases by capsule endoscopy"],"prefix":"10.1111","volume":"13","author":[{"given":"Yuka","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine 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