{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:45:37Z","timestamp":1697445937997},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify the usefulness of transnasal esophagogastroduodenoscope (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>) with all flexible imaging color enhancement (<jats:styled-content style=\"fixed-case\">FICE)<\/jats:styled-content> patterns (0\u20139) for the diagnosis of esophageal varices (<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 50 patients with <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> were examined during the same period by <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> without sedation and by peroral endoscopy (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>) with sedation. The visibility of treatment scars, microvessels, recurrent <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> and red color sign (<jats:styled-content style=\"fixed-case\">RCS<\/jats:styled-content>) were measured. Visibility was evaluated by five blinded observers (poor\u2013good: 0\u201310), and the effect of both endoscopic examinations on the cardiorespiratory function of the patients was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The image scores for <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with ordinary mode and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> were 7.3\u2009\u00b1\u20091.2, 6.1\u2009\u00b1\u20091.0 and 6.9\u2009\u00b1\u20091.0 for treatment scars; 7.2\u2009\u00b1\u20091.4, 6.2\u2009\u00b1\u20091.2 and 7.3\u2009\u00b1\u20091.0 for microvessels; 7.2\u2009\u00b1\u20091.2, 6.1\u2009\u00b1\u20091.0 and 7.1\u2009\u00b1\u20091.0 for recurrent <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> and 7.2\u2009\u00b1\u20091.3, 6.1\u2009\u00b1\u20091.3, and 7.2\u2009\u00b1\u20091.2 for <jats:styled-content style=\"fixed-case\">RCS<\/jats:styled-content>, respectively (intraclass correlation coefficients &gt;\u20090.6). When <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> patterns 2, 6 and 9 were used, visibility was much improved. Ten minutes after insertion, the double product values in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with the <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> group were significantly better (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> is very useful for the diagnosis of <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> and can improve the visibility of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> on each lesion to the same level as that of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>. N\u2010<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> does not require sedation and may reduce the risk of hepatic encephalopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1751-2980.2012.00643.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T11:47:07Z","timestamp":1347968827000},"page":"634-641","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Flexible imaging color enhancement improves visibility of transnasal endoscopic images in diagnosing esophageal varices: A multicenter prospective blinded study"],"prefix":"10.1111","volume":"13","author":[{"given":"Yoshihiro","family":"Furuichi","sequence":"first","affiliation":[{"name":"Fourth Department of Internal Medicine  Tokyo 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