{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:20:42Z","timestamp":1791444042331,"version":"4.3.3"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T00:00:00Z","timestamp":1310342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    <jats:italic>J Clin Hypertens (Greenwich)<\/jats:italic>\n                    . 2011;13:621\u2013627. \u00a92011 Wiley Periodicals, Inc.\n                  <\/jats:p>\n                  <jats:p>Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur\u2010containing antioxidants (N\u2010acetyl\u2010L\u2010cysteine, alpha\u2010lipoic acid, L\u2010glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega\u20103 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima\u2010media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega\u20103 fatty acids. Mercury inactivates catecholaminei\u20100\u2010methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury\u2010induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.<\/jats:p>","DOI":"10.1111\/j.1751-7176.2011.00489.x","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T08:33:26Z","timestamp":1310373206000},"page":"621-627","source":"Crossref","is-referenced-by-count":355,"title":["Role of Mercury Toxicity in Hypertension, Cardiovascular Disease, and Stroke"],"prefix":"10.1111","volume":"13","author":[{"given":"Mark C.","family":"Houston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,11]]},"reference":[{"key":"e_1_2_12_2_2","unstructured":"KeatingMH MahaffeyKR SchoemyR et\u00a0al.Mercury Study Report to Congress. Vol. I. Executive Summary. EPA\u2010452\/R\u201097\u2010003. 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