{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:50:39Z","timestamp":1791251439866,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T00:00:00Z","timestamp":1323388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Furosemide is the diuretic of choice for the treatment of hypertension in chronic kidney disease but the adaptative changes in the distal nephron may decrease its efficacy. Hydrochlorothiazide is not believed to be efficient in this setting. In a randomized, double\u2010blind, cross\u2010over trial, 23 patients with hypertension and stage 4 or 5 chronic kidney disease received long\u2010acting furosemide (60\u2003mg) and hydrochlorothiazide (25\u2003mg) for 3\u2003months and then both diuretics for 3\u2003months. Sodium and chloride fractional excretions were measured after 3\u2003months of each diuretic and then after their association. A trend towards an increase in the fractional excretion of sodium and chloride was observed with furosemide and hydrochlorothiazide (P=not significant). The association of the two diuretics increased the fractional excretions of sodium and chloride from 3.4\u00b11.8 to 4.9\u00b12.8 and from 3.8\u00b12.0 to 6.0\u00b13.1, respectively (P&lt;.05). Furosemide and hydrochlorothiazide decreased mean blood pressure by the same extent. The association of the two diuretics was more efficient on blood pressure. There were no differences between furosemide and hydrochlorothiazide with respect to natriuresis and blood pressure control in patients with hypertension and chronic kidney disease.<\/jats:p>","DOI":"10.1111\/j.1751-7176.2011.00564.x","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T16:45:37Z","timestamp":1323449137000},"page":"32-37","source":"Crossref","is-referenced-by-count":74,"title":["A Pilot Study Comparing Furosemide and Hydrochlorothiazide in Patients With Hypertension and Stage 4 or 5 Chronic Kidney Disease"],"prefix":"10.1111","volume":"14","author":[{"given":"Bertrand","family":"Dussol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Moussi\u2010Frances","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Morange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Somma\u2010Delpero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Mundler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvon","family":"Berland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403313301301"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90155-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90069-2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00630285"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.246"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113847"},{"key":"e_1_2_7_8_2","first-page":"2123","volume-title":"Kidney","author":"Wilcox CS","year":"1991"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.23.2.200"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808063390607"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh650"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542150"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195908"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199509000-00008"},{"key":"e_1_2_7_15_2","first-page":"357","article-title":"Efficacy and safety of metozalone in renal failure and the nephrotic syndrome","volume":"13","author":"Bennett WM","year":"1973","journal-title":"J Clin Pharmacol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_7_17_2","first-page":"2679","volume-title":"Oxford Text Book of Clinical Nephrology","author":"Greger R","year":"1998"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V133798"},{"key":"e_1_2_7_19_2","first-page":"1871","volume-title":"The Kidney","author":"Meyer TW","year":"1991"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197812072992307"},{"key":"e_1_2_7_21_2","first-page":"62","article-title":"Evidence for operation of the magnification phenomenon in patients with chronic renal insufficiency","volume":"9","author":"Epstein M","year":"1983","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_2_7_22_2","first-page":"F1256","article-title":"Adaptation of distal tubule and collecting duct to increased sodium delivery I. 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