{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:24:09Z","timestamp":1790555049916,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>J Clin Hypertens (Greenwich)<\/jats:italic>. 2012; 14:593\u2013600. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><jats:p>The data on the risk of hypertension in human immunodeficiency virus (HIV)\u2013infected patients, particularly in those with lipodystrophy, are controversial. The authors assessed the impact of lipodystrophy on hypertension in a cohort of HIV\u2010infected adults receiving combination antiretroviral therapy. This was a cross\u2010sectional study in which lipodystrophy (clinically and fat mass ratio [FMR]\u2013defined), blood pressure, and body composition (dual\u2010energy x\u2010ray absorptiometry and computed tomography) were evaluated in 368 HIV adults. The prevalence of hypertension in HIV patients with or without clinically or FMR\u2010defined lipodystrophy was similar (with clinical lipodystrophy 35.3% vs without 32.9%, not significant; with FMR lipodystrophy 41.7% vs without 32.2%, not significant). When HIV\u2010infected patients were classified into 4 categories of fat distribution (based on the presence or absence of lipoatrophy and abdominal prominence), isolated lipoatrophy was not significantly associated with hypertension, but patients with isolated central fat accumulation and mixed forms of lipodystrophy had a significantly higher prevalence of hypertension. Hypertensive HIV patients had significantly higher total fat, central, and central\/peripheral fat mass ratio than normotensive ones. After adjustment for age, sex, smoking, and body mass index, hypertension remains significantly associated with central\/peripheral fat mass ratio (odds ratio, 1.258; 95% confidence interval, 1.008\u20131.569). Hypertension was not more prevalent in lipodystrophic HIV\u2010infected patients, but was significantly associated with central\/peripheral fat mass ratio.<\/jats:p>","DOI":"10.1111\/j.1751-7176.2012.00671.x","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T13:44:28Z","timestamp":1339595068000},"page":"593-600","source":"Crossref","is-referenced-by-count":21,"title":["Central\/Peripheral Fat Mass Ratio Is Associated With Increased Risk of Hypertension in HIV\u2010Infected Patients"],"prefix":"10.1111","volume":"14","author":[{"given":"Paula","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio Jos\u00e9","family":"Madureira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Xerinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199907090-00001"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00003"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000222074.45372.00"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200104130-00021"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03913.x"},{"key":"e_1_2_8_7_2","first-page":"294","article-title":"Metabolic disorders and cardiovascular risk in HIV\u2010infected patients treated with antiretroviral agents","volume":"3","author":"Fantoni M","year":"2002","journal-title":"Ital Heart J"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960241011"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00472-6"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.257"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/317541"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200110190-00013"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0002-9629(15)40512-9","article-title":"Absence of age\u2010related increase in systolic blood pressure in ambulatory patients with HIV infection","volume":"317","author":"Mattana J","year":"1999","journal-title":"Am J Med Sci"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1253"},{"key":"e_1_2_8_15_2","unstructured":"LundgrenJD BehrensG CollinsS et\u00a0al.Guidelines prevention and management of non\u2010infectious co\u2010morbidities in HIV. 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