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However, when prescribing antihypertensive therapies to high\u2010risk patients, physicians must be aware of the risks of treatment\u2010related adverse events of hyperkalemia and peripheral edema associated with RAAS inhibitors and CCBs, respectively. This review discusses the use of single\u2010pill combination antihypertensive therapy to optimize BP control in high\u2010risk patients with CKD, diabetes, and\/or heart failure and provides strategies for preventing and managing hyperkalemia and peripheral edema in this group. Single\u2010pill combination therapy can utilize different classes of antihypertensive drugs to reduce BP while mitigating the risks of treatment\u2010related adverse events, reducing pill burden, lowering medical cost, and improving patient compliance.<\/jats:p>","DOI":"10.1111\/j.1751-7176.2012.00696.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T12:32:22Z","timestamp":1344861142000},"page":"718-726","source":"Crossref","is-referenced-by-count":8,"title":["Role of Single\u2010Pill Combination Therapy in Optimizing Blood Pressure Control in High\u2010Risk Hypertension Patients and Management of Treatment\u2010Related Adverse Events"],"prefix":"10.1111","volume":"14","author":[{"given":"Abdul Ali","family":"Abdellatif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"103","article-title":"Vital 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