{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:35Z","timestamp":1790810915047,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T00:00:00Z","timestamp":1346803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There has been considerable interest in identifying and addressing the specific needs of early\u2010episode patients diagnosed with schizophrenia in the hope that by addressing such needs early, chronic disabilities can be avoided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twenty\u2010eight early\u2010episode and 571 chronic patients were compared on socio\u2010demographic characteristics, clinical symptoms and history of childhood trauma. Symptoms were measured with the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ositive and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>egative <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>yndrome <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale (<jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content>), and trauma with the short version of the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildhood <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rauma <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First\u2010episode patients scored 9.3% higher than chronic patients on the <jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content> positive symptom scale and 16.3% lower on the negative symptom scale. More first episode patients reported childhood sexual abuse (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.033); however, fewer reported childhood emotional neglect (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.01). Childhood trauma was associated with positive symptoms, specifically with hallucinations in first\u2010episode patients (<jats:italic>r<\/jats:italic>\u2009=\u20090.174; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.049). Moreover, fewer parents of first episode patients were living alone (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.008). On multiple logistic regression, the first\u2010episode patients were younger (odds ratio\u2009=\u20090.92), had higher <jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content> positive symptom scores (odds ratio 1.04) and lower negative symptom scores (odds ratio 0.948 recalculate).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More positive symptoms, fewer negative symptoms, less isolated parents and greater risk of childhood sexual abuse might warrant attention in first episode schizophrenia and perhaps should be a focus for the development of targeted interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1751-7893.2012.00387.x","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T10:20:47Z","timestamp":1346840447000},"page":"23-30","source":"Crossref","is-referenced-by-count":47,"title":["Comparison of first\u2010episode and chronic patients diagnosed with schizophrenia: symptoms and childhood 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rosenheck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,5]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Dementia Praecox or the Group of Schizophrenias","author":"Bleuler 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