{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:23:42Z","timestamp":1762338222650},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T00:00:00Z","timestamp":1345420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Asthma control and quality of life are poorly associated with traditional asthma biomarkers.<\/jats:p><\/jats:sec>Objectives<\/jats:title>In the present study, we evaluated two new cough provocation tests in this respect.<\/jats:p><\/jats:sec>Methods<\/jats:title>A<\/jats:styled-content>sthma C<\/jats:styled-content>ontrol Q<\/jats:styled-content>uestionnaire and L<\/jats:styled-content>eicester C<\/jats:styled-content>ough Q<\/jats:styled-content>uestionnaire were completed by 36 stable asthmatics. Cough provocation tests with hypertonic saline and isocapnic hyperpnoea of dry air were performed, as well as spirometry, ambulatory peak expiratory flow (PEF<\/jats:styled-content>) monitoring and exhaled nitric oxide (eNO<\/jats:styled-content>) measurement.<\/jats:p><\/jats:sec>Results<\/jats:title>L<\/jats:styled-content>eicester C<\/jats:styled-content>ough Q<\/jats:styled-content>uestionnaire score correlated closely with cough responsiveness to hypertonic saline and isocapnic hyperpnoea (R<\/jats:styled-content>\u2009=\u2009\u22120.66, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 and R<\/jats:styled-content>\u2009=\u2009\u22120.49, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002, respectively). A<\/jats:styled-content>sthma C<\/jats:styled-content>ontrol Q<\/jats:styled-content>uestionnaire score also correlated with the cough responsiveness to these tests (R<\/jats:styled-content>\u2009=\u20090.52, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001 and R<\/jats:styled-content>\u2009=\u20090.43, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.008, respectively). Forced expiratory volume in 1\u2009s (%predicted), diurnal PEF<\/jats:styled-content> variation and eNO<\/jats:styled-content> did not correlate with cough\u2010related quality of life but showed some association with asthma control. There was a significant correlation between L<\/jats:styled-content>eicester C<\/jats:styled-content>ough Q<\/jats:styled-content>uestionnaire and A<\/jats:styled-content>sthma C<\/jats:styled-content>ontrol Q<\/jats:styled-content>uestionnaire (R<\/jats:styled-content>\u2009=\u2009\u22120.54, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Asthma control and cough\u2010related quality of life are more closely associated with cough responsiveness to the investigated cough provocation tests than to eNO<\/jats:styled-content> and traditional indices of bronchial obstruction. Cough is a major contributor to poor asthma control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1752-699x.2012.00313.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T12:03:11Z","timestamp":1343044991000},"page":"253-260","source":"Crossref","is-referenced-by-count":21,"title":["Determinants of asthma control and quality of life in stable asthma: evaluation of two new cough provocation tests"],"prefix":"10.1111","volume":"7","author":[{"given":"Minna","family":"Purokivi","sequence":"first","affiliation":[{"name":"Center for Medicine and Clinical Research Division of Respiratory Medicine Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Koskela","sequence":"additional","affiliation":[{"name":"Center for Medicine and Clinical Research Division of Respiratory Medicine Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Kontra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71087-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039707"},{"key":"e_1_2_6_5_1","unstructured":"GINA.Global strategy for asthma management and prevention global initiative for asthma (GINA).2008. 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