{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:24:22Z","timestamp":1758702262931},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>While the severity of stable chronic obstructive pulmonary disease (COPD<\/jats:styled-content>) has been defined in a valid and relevant prognostic manner, parameters that describe the course of COPD<\/jats:styled-content> exacerbations are not yet established. Physical performance and dyspnoea are of prognostic relevance in stable COPD<\/jats:styled-content>. The issue investigated was to assess the course of COPD<\/jats:styled-content> exacerbations to find parameters that describe this situation better.<\/jats:p><\/jats:sec>Methods<\/jats:title>In 82 hospitalised patients with acute exacerbation of COPD<\/jats:styled-content> who responded to intensified medical treatment (age 67.3\u2009\u00b1\u20099.5\u2009years; forced expiratory volume in 1\u2009s 1.0l, 40% predicted), we measured the 6\u2010min walk distance and the visual analogue scale dyspnoea scores before the start of treatment, prior to discharge and after a 4\u2010week stable period. Additionally, the conventional clinical parameters of COPD<\/jats:styled-content> and quality of life were documented.<\/jats:p><\/jats:sec>Results<\/jats:title>The 6\u2010min walk distance was significantly increased from 97\u2009\u00b1\u2009114\u2009m to 290\u2009\u00b1\u2009106\u2009m. After 4\u2009weeks of outpatient treatment in clinically stable patients, the 6\u2010min walk distance fell non\u2010significantly to 270\u2009\u00b1\u2009120\u2009m. The increment in walk distance fell significantly with advancing severity of COPD<\/jats:styled-content>: from 112\u2009\u00b1\u200968\u2009m for grade I<\/jats:styled-content> and II<\/jats:styled-content> to 56\u2009\u00b1\u200988\u2009m for grade IV<\/jats:styled-content>. Resting as well as exertional dyspnoea scores were significantly reduced (resting dyspnoea from 4 to 2 and exertional dyspnoea from 8 to 6).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We were able to demonstrate that 6\u2010min walk test and dyspnoea scores, but not pulmonary function test, are suitable parameters to assess the course of COPD<\/jats:styled-content> exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1752-699x.2012.00314.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T12:01:40Z","timestamp":1343044900000},"page":"261-267","source":"Crossref","is-referenced-by-count":7,"title":["Six\u2010minute walk distance and dyspnoea scores to assess the course of COPD<\/scp> exacerbation in elderly patients"],"prefix":"10.1111","volume":"7","author":[{"given":"Thomas","family":"Blankenburg","sequence":"first","affiliation":[{"name":"Second Medical Clinic Hospital Martha\u2010Maria Halle\u2010Doelau Halle 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