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Real\u2010time RT\u2010PCR has revealed that HOPP has decreased mRNA levels of Kir6.2, a pore\u2010forming K<jats:sub>ATP<\/jats:sub> channel subunit, without affecting the expression of other K<jats:sub>ATP<\/jats:sub> channel\u2010forming proteins. Based on these findings, we conclude that HOPP could be associated with impaired expression of Kir6.2 which leads to deficiency in skeletal muscle K<jats:sub>ATP<\/jats:sub> channels, which may explain the symptoms and clinical signs of this disease.<\/jats:p>","DOI":"10.1111\/j.1752-8062.2008.00007.x","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T15:23:00Z","timestamp":1211383380000},"page":"71-74","source":"Crossref","is-referenced-by-count":16,"title":["A Patient Suffering from Hypokalemic Periodic Paralysis Is Deficient in Skeletal Muscle ATP\u2010sensitive K<sup>+<\/sup> channels"],"prefix":"10.1111","volume":"1","author":[{"given":"Sofija","family":"Jovanovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyou","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somnath","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Swingler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"McEachen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Jovanovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-002-0055-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.5.C1351"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00064.2005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4552"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00747.2007"},{"key":"e_1_2_7_7_2","first-page":"479","article-title":"KATP channel pharmacogenomics: from bench to bedside","volume":"82","author":"Sattiraju S","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00053-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121038198"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0466fje"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf388"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400489"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.383"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01428-0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303051200"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00415-8"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01947-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5483com"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.6.C1936"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00303.2002"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1752-8062.2008.00007.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1752-8062.2008.00007.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T17:54:31Z","timestamp":1697392471000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/j.1752-8062.2008.00007.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1111\/j.1752-8062.2008.00007.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1752-8062.2008.00007.x","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}