{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:24:44Z","timestamp":1772497484996,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1492,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1111\/j.1752-8062.2011.00301.x","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T16:51:50Z","timestamp":1314809510000},"page":"253-258","source":"Crossref","is-referenced-by-count":24,"title":["High Levels of Zinc-Protoporphyrin Identify Iron Metabolic Abnormalities in Pulmonary Arterial Hypertension"],"prefix":"10.1111","volume":"4","author":[{"given":"Ilka","family":"Decker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudakshina","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzy A.","family":"Comhair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"Farha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Hong","family":"Wilson Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Lichtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil C.","family":"Erzurum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,29]]},"reference":[{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1183\/09031936.00175909","article-title":"Pulmonary hypertension in patients with chronic myeloproliferative disorders","volume":"35","author":"Adir","year":"2010","journal-title":"Eur Respir J."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1172\/JCI36362","article-title":"Christofidou-Solomidou M., and Simon M.C. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice","volume":"120","author":"Hickey","year":"2010","journal-title":"J Clin Invest."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1378\/chest.99.5.1208","article-title":"Familial pulmonary hypertension in association with an abnormal hemoglobin. Insights into the pathogenesis of primary pulmonary hypertension","volume":"99","author":"Rich","year":"1991","journal-title":"Chest."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1113\/jphysiol.2008.160960","article-title":"The increase in pulmonary arterial pressure caused by hypoxia depends on iron status","volume":"586","author":"Smith","year":"2008","journal-title":"J Physiol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1001\/jama.2009.1404","article-title":"Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials","volume":"302","author":"Smith","year":"2009","journal-title":"JAMA."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1152\/jappl.2001.90.6.2502","article-title":"Selected Contribution: pulmonary hypertension in mice following intermittent hypoxia","volume":"90","author":"Fagan","year":"2001","journal-title":"J Appl Physiol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra035488","article-title":"Pulmonary arterial hypertension","volume":"351","author":"Farber","year":"2004","journal-title":"N Engl J Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1161\/CIRCULATIONAHA.104.503540","article-title":"Pulmonary arterial hypertension","volume":"114","author":"McLaughlin","year":"2006","journal-title":"Circulation."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1055\/s-0029-1233315","article-title":"Pulmonary hypertension in chronic obstructive pulmonary disease and interstitial lung diseases","volume":"30","author":"Weitzenblum","year":"2009","journal-title":"Semin Respir Crit Care Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB10|cit10","unstructured":"Krasuski RA Hart SA Smith B Wang A Harrison JK Bashore TM Association of anemia and long-term survival in patients with pulmonary hypertension"},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1183\/09031936.00100510","article-title":"Iron deficiency is common in idiopathic pulmonary arterial hypertension","volume":"37","author":"Ruiter","year":"2011","journal-title":"Eur Respir J."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/clinchem\/45.12.2060","article-title":"Zinc protoporphyrin: a metabolite with a mission","volume":"45","author":"Labbe","year":"1999","journal-title":"Clin Chem."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/clinchem\/40.5.768","article-title":"Central role of zinc protoporphyrin in staging iron deficiency","volume":"40","author":"Hastka","year":"1994","journal-title":"Clin Chem."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V81.5.1200.1200","article-title":"Zinc protoporphyrin in anemia of chronic disorders","volume":"81","author":"Hastka","year":"1993","journal-title":"Blood."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/j.jacc.2004.02.037","article-title":"Clinical classification of pulmonary hypertension","volume":"43","author":"Simonneau","year":"2004","journal-title":"J Am Coll Cardiol."},{"issue":"Suppl 1)","key":"10.1111\/j.1752-8062.2011.00301.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.3949\/ccjm.70.Suppl_1.S2","article-title":"Primary pulmonary hypertension: an overview of epidemiology and pathogenesis","volume":"70(","author":"Ghamra","year":"2003","journal-title":"Cleve Clin J Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force","volume":"22","year":"1999","journal-title":"Sleep."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide.","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0002-9149(90)90711-9","article-title":"Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava","volume":"66","author":"Kircher","year":"1990","journal-title":"Am J Cardiol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.amjcard.2009.05.016","article-title":"Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension","volume":"104","author":"Hampole","year":"2009","journal-title":"Am J Cardiol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1111\/j.1742-4658.2009.07120.x","article-title":"Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain","volume":"276","author":"Stuehr","year":"2009","journal-title":"Febs J."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1161\/CIRCULATIONAHA.109.916098","article-title":"Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target","volume":"121","author":"Archer","year":"2010","journal-title":"Circulation."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2353\/ajpath.2010.090832","article-title":"Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells","volume":"176","author":"Fijalkowska","year":"2010","journal-title":"Am J Pathol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1164\/ajrccm.158.3.9802066","article-title":"Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension","volume":"158","author":"Kaneko","year":"1998","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.freeradbiomed.2004.06.039","article-title":"Nitric oxide and pulmonary arterial pressures in pulmonary hypertension","volume":"37","author":"Machado","year":"2004","journal-title":"Free Radic Biol Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004080000064","article-title":"High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy","volume":"179","author":"Ozkan","year":"2001","journal-title":"Lung."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1096\/fj.04-2317fje","article-title":"Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension","volume":"18","author":"Xu","year":"2004","journal-title":"Faseb J."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1073\/pnas.0605080104","article-title":"Alterations of cellular bioenergetics in pulmonary artery endothelial cells","volume":"104","author":"Xu","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease","volume":"352","author":"Weiss","year":"2005","journal-title":"N Engl J Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2353\/ajpath.2008.070705","article-title":"Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension","volume":"172","author":"Asosingh","year":"2008","journal-title":"Am J Pathol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"L789","DOI":"10.1152\/ajplung.90306.2008","article-title":"High levels of hyaluronan in idiopathic pulmonary arterial hypertension","volume":"295","author":"Aytekin","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1183\/09031936.03.00038903","article-title":"Inflammation in pulmonary arterial hypertension","volume":"22","author":"Dorfmuller","year":"2003","journal-title":"Eur Respir J."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","article-title":"Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension","volume":"122","author":"Soon","year":"2010","journal-title":"Circulation."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/thx.2010.147272","article-title":"Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension","volume":"66","author":"Soon","year":"2011","journal-title":"Thorax."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1182\/blood.V89.3.1052","article-title":"Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency","volume":"89","author":"Punnonen","year":"1997","journal-title":"Blood."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N Engl J Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cardfail.2009.05.010","article-title":"A pilot evaluation of the long-term effect of combined therapy with intravenous iron sucrose and erythropoietin in elderly patients with advanced chronic heart failure and cardio-renal anemia syndrome: influence on neurohormonal activation and clinical outcomes","volume":"15","author":"Comin-Colet","year":"2009","journal-title":"J Card Fail."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archinternmed.2009.11","article-title":"Red blood cell distribution width and the risk of death in middle-aged and older adults","volume":"169","author":"Patel","year":"2009","journal-title":"Arch Intern Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/archinternmed.2009.55","article-title":"Red blood cell distribution width and mortality risk in a community-based prospective cohort","volume":"169","author":"Perlstein","year":"2009","journal-title":"Arch Intern Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1164\/rccm.200706-840OC","article-title":"Procoagulant membrane microparticles correlate with the severity of pulmonary arterial hypertension","volume":"177","author":"Bakouboula","year":"2008","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.thromres.2010.06.020","article-title":"Enhanced hemostatic indices in patients with pulmonary arterial hypertension: an observational study","volume":"126","author":"Can","year":"2010","journal-title":"Thromb Res."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/ajh.20640","article-title":"Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state","volume":"81","author":"Singer","year":"2006","journal-title":"Am J Hematol."},{"key":"10.1111\/j.1752-8062.2011.00301.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1182\/blood-2006-12-061697","article-title":"Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin","volume":"110","author":"Villagra","year":"2007","journal-title":"Blood"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1752-8062.2011.00301.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1752-8062.2011.00301.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:10:18Z","timestamp":1625569818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1752-8062.2011.00301.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1752-8062.2011.00301.x","relation":{},"ISSN":["1752-8054"],"issn-type":[{"value":"1752-8054","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}