{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T08:21:12Z","timestamp":1781425272988,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The aim of the present study was to evaluate the antioxidant potential of embelin in streptozotocin\u2010induced diabetes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Diabetes was induced in rats fasted overnight by the administration of a single dose of streptozotocin, and analyzed for blood, serum, and biological and histological pancreatic tissue parameters in intact control, diabetic, and embelin\u2010treated diabetic rats (<jats:italic>n<\/jats:italic>\u2003=\u20039) at the dose levels of 15, 25, and 30\u2003mg\/kg\/day for 21\u2003days.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Diabetes caused highly significant abnormalities in blood, serum, and pancreatic tissue biochemical parameters. Embelin and glibenclamide administration to diabetic rats caused a highly significant decline in the blood glycated hemoglobin and serum glucose levels and nitric oxide activity, with a concomitant increase in the serum insulin level (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Furthermore, embelin and glibenclamide treatment increased the pancreatic antioxidant enzyme status (superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, glutathione <jats:italic>S<\/jats:italic>\u2010transferase, and ascorbic acid), and also decreased the thiobarbituric acid reactive oxygen species contents (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The histoarchitecture of the diabetic rats typically showed a degenerated pancreas with reduced \u03b2\u2010cell counts, while embelin treatment was shown to significantly regenerate islet cells.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The study proves the potent antioxidant activity of embelin, which has been found to be effective in managing severe hyperglycemia.<\/jats:p>","DOI":"10.1111\/j.1753-0407.2012.00187.x","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T23:11:36Z","timestamp":1326841896000},"page":"248-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Antioxidant activity and protection of pancreatic <i>\u03b2<\/i>\u2010cells by embelin in streptozotocin\u2010induced 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