{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:50:45Z","timestamp":1794556245225,"version":"4.9.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Musa sapientum<\/jats:italic> Linn. is a herbaceous plant of the Musaceae family. It has been used in India for the treatment of gastric ulcer, hypertension, diarrhea, dysentery, and diabetes. The antidiabetic effect of the fruit, root, and flower has been demonstrated. The aim of the present study was to assess the antidiabetic and antihyperlipidemic effects of the stem of <jats:italic>M.\u00a0sapientum<\/jats:italic> Linn.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Diabetes was induced in rats by streptozotocin injection (45\u2003mg\/kg, i.p.). Diabetic rats were treated for 2\u2003weeks with different doses of lyophilized stem juice of <jats:italic>M.\u00a0sapientum<\/jats:italic> Linn. (25, 50, and 100\u2003mg\/kg) to select the most effective dose. The effects of 4\u2003weeks treatment with this dose (50\u2003mg\/kg) on fasting and postprandial plasma glucose (FPG, PPG) levels, body weight, lipid profile, HbA1c, insulin, liver enzymes (i.e. glucokinase, glucose\u20106\u2010phosphatase and 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme A [HMG\u2010CoA] reductase) and muscle and liver glycogen were evaluated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The most effective dose of lyophilized stem juice of <jats:italic>M.\u00a0sapientum<\/jats:italic> Linn. was 50\u2003mg\/kg. Four weeks treatment with this dose resulted in significant decreases in FPG and PPG (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). Serum insulin increased (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) whereas HbA1c decreased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Diabetes\u2010induced changes to the lipid profile, muscle and liver glycogen, and enzyme activity (i.e. glucokinase, glucose\u20106\u2010phosphatase, and HMG\u2010CoA reductase) were restored near to normal levels (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Diabetic rats responded favorably to treatment with lyophilized stem juice of <jats:italic>M.\u00a0sapientum<\/jats:italic> Linn., which exhibits antidiabetic and antihyperlipidemic effects.<\/jats:p>","DOI":"10.1111\/j.1753-0407.2012.00198.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T14:02:37Z","timestamp":1332165757000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antidiabetic and antihyperlipidemic effects of the stem of <i>Musa sapientum<\/i> Linn. in streptozotocin\u2010induced diabetic 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