{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:58:58Z","timestamp":1786769938977,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims:<\/jats:bold> Primary gastric extramedullary plasmacytoma is an extremely rare condition and there is scant information in the literature concerning its natural history or therapy. There have been anecdotal reports of surgical resection, with or without <jats:italic>Helicobacter pylori<\/jats:italic> eradication, but there are no useful reports of the role of radiotherapy. We report the clinicopathologic outcome of radical radiotherapy as a primary treatment modality.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We identified two patients with biopsy\u2010proven primary gastric extramedullary plasmacytoma. Routine staging investigations were performed and <jats:italic>H.\u2003pylori<\/jats:italic> status was determined. Radical radiotherapy to 41.4\u2003Gy in 23 fractions was delivered using conformal techniques. The target volume was the stomach with a 1\u2010cm margin. Prophylactic anti\u2010emetic was administered prior to each fraction. Post\u2010treatment endoscopies and biopsies were performed at 3\u2010monthly intervals to assess clinicopathological response. Treatment\u2010related toxicities were documented.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both patients achieved durable (&gt;12\u2003months) pathologically confirmed complete remissions without significant toxicities.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Radical radiotherapy offers the potential for cure and organ preservation with low toxicity. It should be considered a favourable alternative to surgery in the management of this rare disease entity.<\/jats:p>","DOI":"10.1111\/j.1754-9485.2012.02369.x","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T07:45:05Z","timestamp":1334043905000},"page":"328-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Complete remission of localised gastric plasmacytomas following definitive radiotherapy"],"prefix":"10.1111","volume":"56","author":[{"given":"Jennifer","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Opat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Mac Manus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2305::AID-CNCR2>3.0.CO;2-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0587-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8341"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0903-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.370"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.08.037"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12654"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.373"},{"key":"e_1_2_6_10_2","first-page":"47","article-title":"Clinical outcome of extramedullary plasmacytoma","volume":"85","author":"Galieni P","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.039"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.077"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.162"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00804.x"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1754-9485.2012.02369.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1754-9485.2012.02369.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T20:18:57Z","timestamp":1697401137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1754-9485.2012.02369.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,10]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1754-9485.2012.02369.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1754-9485.2012.02369.x","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,10]]},"assertion":[{"value":"2012-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}