{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:32:49Z","timestamp":1746185569026},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:<\/jats:bold> To assess the potential role of 18F\u2010Fluorodeoxiglucose (FDG) Positron Emission Tomography (PET)\/Computed Tomography (CT) in characterizing indeterminate lung nodules detected at CT scan in patients previously treated for a breast cancer (BC).<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> Twenty\u2010nine consecutive BC patients (28 females, mean age 65\u2003\u00b1\u200312\u2003years) with evidence of indeterminate lung nodules at contrast\u2010enhanced CT (CECT) scan (lesions with axial diameter \u22658\u2003mm) were retrospectively analysed: all patients underwent 18F\u2010FDG PET\/CT within a mean 2\u2003\u00b1\u20031\u2003months from CECT imaging. PET\/CT was considered positive in the presence of abnormal FDG uptake in the pulmonary nodules and\/or in other organs. The nature of lung nodules was defined at histopathology and\/or imaging follow\u2010up.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Fourteen (48%) patients showed negative and 15 (52%) positive PET\/CT scan in the lungs: of these 15 patients, 7 (47%) had pathologic FDG\u2010uptake in lungs only, whereas 8 (53%) showed abnormal FDG\u2010uptake also in sites different from lungs. At histology and\/or imaging follow\u2010up, five (17%) patients were considered positive for BC lung metastases while in seven (24%) a second cancer was diagnosed. In this subset of patients, the sensitivity and specificity for FDG PET\/CT in revealing lung lesions were 17% and 100%, respectively, for nodules &lt;8\u2003mm in diameter, and 77% and 85%, respectively, for nodules with diameter \u22658\u2003mm.<\/jats:p><jats:p>The therapeutic planning was changed to surgery in seven patients, chemotherapy in one patient and continued hormonal therapy in five. The inclusion of PET\/CT in the diagnostic algorithm of the evaluated patients helped avoid unnecessary over\u2010treatment in 12 of 29 patients.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> FDG PET\/CT appears useful in characterizing indeterminate lung nodules found at CECT scan in BC patients, with a sensitivity that is proportional to nodule size. In addition, PET\/CT helped in avoiding over\u2010treatment in a significant proportion of patients.<\/jats:p>","DOI":"10.1111\/j.1754-9485.2012.02408.x","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T03:16:08Z","timestamp":1342667768000},"page":"417-424","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Indeterminate pulmonary nodules on CT images in breast cancer patient: The additional value of 18F\u2010FDG PET\/CT"],"prefix":"10.1111","volume":"56","author":[{"given":"Laura","family":"Evangelista","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalori","family":"Panunzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rita","family":"Cervino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Vinante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Al\u2010Nahhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Rubello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Carlo","family":"Muzzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Polverosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2372041887"},{"key":"e_1_2_5_3_2","unstructured":"RiesLAG HarkinsD KrapchoMet\u2003al.SEER Cancer Statistics Review 1975\u20132003. 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