{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:50:11Z","timestamp":1760298611794},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The purpose of the study is to investigate the clinical value of F<\/jats:styled-content>\u201018 fluorodeoxyglucose positron emission tomography\/computed tomography (FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content>) in detecting the primary sites in patients with carcinoma of unknown primary (CUP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>The reports of FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> scans of 164 patients with CUP<\/jats:styled-content> syndrome in consecutive 2589 patients referred to our department from J<\/jats:styled-content>anuary 2006 to J<\/jats:styled-content>une 2010 were retrospectively reviewed. The final results were obtained from the pathologic reports, other imaging modalities diagnoses and clinical follow\u2010up data.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 142 cases in the results analysis, as 19 patients were lost to follow\u2010up and three patients were excluded. FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> successfully detected primary tumours in 67 (47.2%) out of 142 patients. Among this group, 53 were pathologically proved and 17 patients were confirmed by clinical follow\u2010up. The primary sites of 38 (56.7%) were in lung, eight (11.9%) in nasopharynx and 13 (19.4%) in digestive system. Six patients were misdiagnosed by FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> scan. FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> could not detect the primary lesion in 66 patients, and three primary tumours were identified by conventional work\u2010up after negative FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> scan. The accuracy, sensitivity and specificity of FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> scan in detecting the primary site in this study were 93.7%, 95.7% and 91.7%, respectively. FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> scan changed the medical management of about 33.8% of 142 CUP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> whole\u2010body imaging is a valuable tool in detecting the primary tumour of patients with CUP<\/jats:styled-content> site.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1754-9485.2012.02441.x","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T11:51:28Z","timestamp":1350474688000},"page":"65-71","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical value of whole\u2010body F<\/scp>\u201018 fluorodeoxyglucose positron emission tomography\/computed tomography in patients with carcinoma of unknown primary"],"prefix":"10.1111","volume":"57","author":[{"given":"Guohui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaopan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanmiao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Interventional Radiology Cancer Center and State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1295-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja48177"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850701581768"},{"key":"e_1_2_6_5_1","first-page":"816","article-title":"FDG PET detection of unknown primary tumors","volume":"41","author":"Bohuslavizki KH","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(00)00053-4"},{"key":"e_1_2_6_7_1","first-page":"15","article-title":"Role of whole body positron emission tomography\/computed tomography scan with 18F\u2010fluorodeoxyglucose in patients with biopsy proven tumor metastases from unknown primary site","volume":"50","author":"Pelosi E","year":"2006","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0456-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20099"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200512000-00003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/108497803321269322"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1194-4"},{"key":"e_1_2_6_14_1","first-page":"222","article-title":"Epidemiology of nasopharyngeal carcinoma","volume":"69","author":"Huang DP","year":"1990","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163098.01398.79"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22410"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328302cd26"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200310000-00008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2312021185"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0580-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.20.3495"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2004.10.002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00221-9"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1754-9485.2012.02441.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1754-9485.2012.02441.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:22:34Z","timestamp":1697347354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1754-9485.2012.02441.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1754-9485.2012.02441.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1754-9485.2012.02441.x","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,17]]},"assertion":[{"value":"2011-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}