{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:46:05Z","timestamp":1792161965663,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the outcomes (survival and adverse events) of the authors' use of <jats:sup>90<\/jats:sup><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> microsphere radioembolisation in patients with chemotherapy\u2010refractory liver metastases with published data from other groups using radioembolisation. To retrospectively evaluate the efficiency, in particular survival benefits, of radioembolisation in the treatment of liver metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Over 5 years, 339 patients underwent <jats:sup>90<\/jats:sup><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> microsphere radioembolisation for unresectable liver metastases and were evaluated for adverse events at the time of treatment and 1 and 3 months after treatment. Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was calculated by the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier method. The results from the present retrospective study were compared with a number of prospective and retrospective clinical trials which have addressed the use of <jats:sup>90<\/jats:sup><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> microspheres as a salvage treatment for liver metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> time of the present study (12.0 months) compares favourably with survival times reported by other groups. The incidence of late grade 2 adverse events (e.g. duodenal or gastric ulceration, radiation\u2010induced liver disease, gall bladder complications) is comparable to previous studies, with a lower prevalence of grade 2\/3 ulcerations (3.7%) at our centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The survival results, together with the low acute and late toxicity observed in our data and previous studies, support the use of radioembolisation to aid in the local control of unresectable liver metastases in the salvage setting. The present study contributes to the growing evidence for efficiency, in particular survival gains, of radioembolisation in the treatment of liver metastases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1754-9485.2012.02459.x","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T06:31:49Z","timestamp":1349764309000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Radioembolisation with <scp>Y<\/scp>ttrium\u201090 microspheres: An effective treatment modality for unresectable liver metastases"],"prefix":"10.1111","volume":"57","author":[{"given":"Lourens","family":"Bester","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology University of New South Wales St. Vincent's Hospital  Darlinghurst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baerbel","family":"Meteling","sequence":"additional","affiliation":[{"name":"Department 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