{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:59:29Z","timestamp":1785509969831,"version":"3.56.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Erectile dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) is a common adverse event associated with treatment for prostate cancer. This study aimed to identify whether early, regular use of sildenafil after radiation treatment for prostate cancer is effective at reducing the rate of <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> at 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled trial with 27 men planned for radiation treatment for localised prostate cancer recruited from a single radiotherapy centre in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. Men were randomised to receive daily sildenafil, or a placebo tablet, for 6 months. The primary end\u2010point was erectile function, as measured by the International Index of Erectile Function (<jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>) score, at 2\u2010year follow\u2010up. The abridged <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 survey was also used during the treatment period, and could be derived from the full <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content> at other time\u2010points. Two\u2010sided Student's <jats:italic>t<\/jats:italic>\u2010tests and Mann\u2013Whitney <jats:italic><jats:styled-content style=\"fixed-case\">U<\/jats:styled-content><\/jats:italic>\u2010tests were used for the analysis of continuous outcomes, with Fisher's exact test for dichotomous outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference was seen at 2 years in the primary end\u2010point, and <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content> scores did not differ significantly between groups during the study. Men in the sildenafil group exhibited significantly better <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 scores at 4 weeks (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u2009<jats:italic>0.02<\/jats:italic>) and 6 months (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u2009<jats:italic>0.02<\/jats:italic>). There was no difference in erectile function scores between the two groups throughout the treatment period. No significant difference in adverse events was identified between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no evidence from this trial that sildenafil provides long\u2010term erectile function for patients while on medication. Regular use of sildenafil may improve short\u2010term sexual function for patients while on medication. Larger trials are required to examine the effectiveness of implementing sildenafil for prostate cancer patients undergoing radiation treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1754-9485.2012.02461.x","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T18:38:47Z","timestamp":1350585527000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A randomised, double\u2010blind, placebo\u2010controlled trial of nightly sildenafil citrate to preserve erectile function after radiation treatment for prostate cancer"],"prefix":"10.1111","volume":"57","author":[{"given":"Dragan","family":"Ilic","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria 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