{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:15:50Z","timestamp":1793420150269,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Our initial experience using recommended high dose per fraction skin brachytherapy (BT<\/jats:styled-content>) treatment schedules, resulted in poor cosmesis. This study aimed to assess in a prospective group of patients the use of L<\/jats:styled-content>eipzig surface applicators for High Dose Rate (HDR<\/jats:styled-content>) brachytherapy, for the treatment of small non\u2010melanoma skin cancers (NMSC<\/jats:styled-content>) using a protracted treatment schedule.<\/jats:p><\/jats:sec>Method<\/jats:title>Treatment was delivered by HDR<\/jats:styled-content> brachytherapy with L<\/jats:styled-content>eipzig applicators. 36\u2009Gy<\/jats:styled-content>, prescribed to between 3 to 4\u2009mm, was given in daily 3\u2009Gy<\/jats:styled-content> fractions. Acute skin toxicity was evaluated weekly during irradiation using the Radiation Therapy Oncology Group criteria. Local response, late skin effects and cosmetic results were monitored at periodic intervals after treatment completion.<\/jats:p><\/jats:sec>Results<\/jats:title>From M<\/jats:styled-content>arch 2002, 200 patients with 236 lesions were treated. Median follow\u2010up was 66 months (range 25\u2013121 months). A total of 162 lesions were macroscopic, while in 74 cases, BT<\/jats:styled-content> was given after resection because of positive microscopic margins. There were 121 lesions that were basal cell carcinomas, and 115 were squamous cell carcinomas. Lesions were located on the head and neck (198), the extremities (26) and trunk (12). Local control was 232\/236 (98%). Four patients required further surgery to treat recurrence. Grade 1 acute skin toxicity was detected in 168 treated lesions (71%) and grade 2 in 81 (34%). Cosmesis was good or excellent in 208 cases (88%). Late skin hypopigmentation changes were observed in 13 cases (5.5%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Delivering 36 Gy<\/jats:styled-content> over 2 weeks to superficial NMSC<\/jats:styled-content> using HDR<\/jats:styled-content> brachytherapy is well tolerated and provides a high local control rate without significant toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1754-9485.2012.02466.x","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T19:04:00Z","timestamp":1351537440000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["HDR<\/scp> Brachytherapy for Superficial Non\u2010Melanoma Skin Cancers"],"prefix":"10.1111","volume":"57","author":[{"given":"Ruth","family":"Gauden","sequence":"first","affiliation":[{"name":"launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pracy","sequence":"additional","affiliation":[{"name":"W.P. Holman Clinic Launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Avery","sequence":"additional","affiliation":[{"name":"W.P. Holman Clinic Launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hodgetts","sequence":"additional","affiliation":[{"name":"W.P. Holman Clinic Launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Gauden","sequence":"additional","affiliation":[{"name":"W.P. Holman Clinic Launceston General Hospital Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"573","volume-title":"The GEC ESTRO Handbook of Brachytherapy","author":"Van Limbergen E","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03039594"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00547-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02852.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2008.02.215"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2008.06.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2008.02.208"},{"issue":"18","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"15543","DOI":"10.1200\/jco.2006.24.18_suppl.15543","article-title":"High dose rate brachytherapy with surface applicators: treatment for nonmelanomatous skin cancer","volume":"24","author":"Musmacher J","year":"2006","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90529-S"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00410-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01656-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02103.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.02.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2825622"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1754-9485.2012.02466.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1754-9485.2012.02466.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:12:42Z","timestamp":1697328762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1754-9485.2012.02466.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1754-9485.2012.02466.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1754-9485.2012.02466.x","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]},"assertion":[{"value":"2012-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}