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We were unable to induce robust and lasting depigmentation in the Hsp70\u20101 knockout mice, and in vivo cytolytic assays revealed a lack of cytotoxic T\u2010lymphocyte activity. Absence of T\u2010cell infiltration to the skin and maintenance of hair follicle melanocytes were observed. By contrast, depigmentation proceeded without interruption in mice lacking a tissue\u2010specific constitutive isoform of HSP70 (Hsp70\u20102) vaccinated with TRP\u20102. Next, we demonstrated that HSP70i was necessary and sufficient to accelerate depigmentation in vitiligo\u2010prone Pmel\u20101 mice, accompanied by lasting phenotypic changes in dendritic cell subpopulations. In summary, these studies assign a unique function to HSP70i in vitiligo and identify HSP70i as a targetable entity for treatment.<\/jats:p>","DOI":"10.1111\/j.1755-148x.2011.00916.x","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T12:40:50Z","timestamp":1317904850000},"page":"88-98","source":"Crossref","is-referenced-by-count":86,"title":["HSP70i is a critical component of the immune response leading to vitiligo"],"prefix":"10.1111","volume":"25","author":[{"given":"Jeffrey A.","family":"Mosenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Zloza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Klarquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison J.","family":"Barfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Guevara\u2010Patino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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