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The aim of this BioGenoMEL collaborative study in 10 melanoma cohorts was to test the hypothesis that inherited variants thereby moderate survival expectation. A survival analysis in the largest cohort (Leeds) was carried out adjusting for factors known to impact on survival. The results were then compared with data from nine smaller cohorts. The absence of any consensus\n                    <jats:italic>MC1R<\/jats:italic>\n                    alleles was associated with a significantly lower risk of death in the Leeds set (HR, 0.64; 95% CI, 0.46\u20130.89) and overall in the 10 data sets (HR, 0.78; 95% CI, 0.65\u20130.94) with some support from the nine smaller data sets considered together (HR, 0.83; 95% CI, 0.67\u20131.04). 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