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The classical <jats:italic>Hairless<\/jats:italic><jats:sup><jats:italic>Hr<\/jats:italic><\/jats:sup><jats:italic>\/Hairless<\/jats:italic><jats:sup><jats:italic>Hr<\/jats:italic><\/jats:sup> mouse mutant loses all hair between 2 and 3\u2003weeks of age. As the mice age, their trunk skin develops epidermal pigmentation, a feature of human skin which is not found in normal haired mice. In this report, we present a new, dominant mouse mutation, <jats:italic>Pied<\/jats:italic>, which arose within a colony of <jats:italic>Hairless<\/jats:italic><jats:sup><jats:italic>Hr<\/jats:italic><\/jats:sup><jats:italic>\/Hairless<\/jats:italic><jats:sup><jats:italic>Hr<\/jats:italic><\/jats:sup> mice and causes freckle\u2010like macules on the skin. The <jats:italic>Pied<\/jats:italic> macules require <jats:italic>Hairless<\/jats:italic><jats:sup><jats:italic>Hr<\/jats:italic><\/jats:sup> homozygosity to form and are composed of localized clusters of epidermal melanocytes. Through linkage analysis, we find that the <jats:italic>Pied<\/jats:italic> mutation is a 1914 base pair loss\u2010of\u2010function deletion in the <jats:italic>Adam10<\/jats:italic> zinc metalloprotease gene. The pathways that specifically maintain long\u2010term pigmentation patterns in adults are not well understood. We have identified Adam10 as an inhibitor of melanocyte expansion in adult skin.<\/jats:p>","DOI":"10.1111\/j.1755-148x.2012.01032.x","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T04:54:52Z","timestamp":1343364892000},"page":"555-565","source":"Crossref","is-referenced-by-count":17,"title":["<i>Adam10<\/i> haploinsufficiency causes freckle\u2010like macules in <i>Hairless<\/i> mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Grace","family":"Tharmarajah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Faas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Saftig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine D.","family":"Van Raamsdonk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00236.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.323"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.120"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507609102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910390324"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505261"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680245"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90696-C"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480997"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1963.142"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08464.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06925.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803233105"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.21.2615"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092080414"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr100556z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.15.2915"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.942302"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01052"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8738"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.18.6559"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091700409"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(73)90337-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20449"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00434.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509084"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1922"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03179.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(00)00098-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/416854a"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65110-3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64621-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701180"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20864"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.916701"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.163.9.4917","article-title":"CD44\u2010deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets","volume":"163","author":"Protin U.","year":"1999","journal-title":"J. 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