{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:21:38Z","timestamp":1769347298254,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T00:00:00Z","timestamp":1243382400000},"content-version":"vor","delay-in-days":10161,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:p>Elevated arterial carbon dioxide tension, induced by the administration of CO<jats:sub>2<\/jats:sub> via the respiratory air or by hypoventilation, entailed a gradual increase in the IOP in patients without eye diseases under general anaesthesia. A sudden cessation of CO<jats:sub>2<\/jats:sub> administration or hyperventilation caused such a rapid, simultaneous fall in IOP to values below the initial level that the pressure variations must be of vascular nature, presumably related to changes in choroidal blood volume. The above\u2010mentioned procedures always cause a change in the central venous pressure (CVP) simultaneously with the IOP changes. Alterations of the CVP induced by hydrostatic factors in postural changes, placing the head 15\u00b0 above or below the horizontal level while keeping the PaCO<jats:sub>2<\/jats:sub> constant, caused IOP changes of the same configuration and magnitude as described above. It is concluded, therefore, that presumably the CO<jats:sub>2<\/jats:sub>\u2010conditioned IOP changes are due predominantly to changes in central venous pressure, being one link in a CO<jats:sub>2<\/jats:sub>\u2010conditioned action upon the general circulation, entailing passive secondary changes in the choroidal venous blood volume and thereby an influence upon the IOP. On the basis of the present results it appears rational to recommend hyperventilation to keep the PaCO<jats:sub>2<\/jats:sub> between 25 and 30 mm and a 15\u00b0 anti\u2010Trendelenburg position in operations on the open eye under general anaesthesia, since both procedures afford a low central venous pressure and consequently a low pressure in the posterior segment of the eye, with its attendant advantages as regards vitreous complications and the insertion of intraocular lenses. Owing to the risk of an unacceptable fall in BP in the combined procedure, a frequent checking of the BP is needed.<\/jats:p>","DOI":"10.1111\/j.1755-3768.1981.tb08331.x","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T22:47:18Z","timestamp":1243464438000},"page":"465-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["EFFECT OF CHANGES IN PC0<sub>2<\/sub> AND BODY POSITIONS ON INTRAOCULAR PRESSURE DURING GENERAL ANAESTHESIA"],"prefix":"10.1111","volume":"59","author":[{"given":"A.","family":"HVIDBERG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SV.V.","family":"KESSING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"FERNANDES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1966.tb02599.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00683360"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990030097018"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1972.01000020072015"},{"key":"e_1_2_1_6_1","first-page":"534","article-title":"Effect of changes in PCO2 on intraocular tension","volume":"16","author":"Kielar R A","year":"1977","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00414618"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1977.tb01215.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1972.tb08192.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.58.1.62"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197704000-00004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1967.tb06523.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1949.tb05848.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1755-3768.1981.tb08331.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1755-3768.1981.tb08331.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T03:25:11Z","timestamp":1699327511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1755-3768.1981.tb08331.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,8]]}},"alternative-id":["10.1111\/j.1755-3768.1981.tb08331.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1755-3768.1981.tb08331.x","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8]]},"assertion":[{"value":"2009-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}