{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:36Z","timestamp":1761894756288},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T00:00:00Z","timestamp":1218499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> We aim to describe the first case of tubulointerstitial nephritis and uveitis (TINU) syndrome reported in Scandinavia and to underline the importance of the syndrome, which should be better known among ophthalmologists.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We report an 11\u2010year\u2010old boy who was admitted to hospital because of general fatigue and weight loss. Blood tests showed renal insufficiency and a renal biopsy revealed acute tubulointerstitial nephritis. One week after admission the patient developed transitory blurred vision and flickering shadows in the left eye. Slit\u2010lamp examination revealed bilateral anterior non\u2010granulomatous uveitis and TINU syndrome was diagnosed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Because of renal insufficiency the patient was treated with systemic prednisone 50\u2003mg\/day for 3\u2003weeks. Evolution was favourable, and prednisone was tapered over 10\u2003weeks. Uveitis was treated with topical steroid with good effect. The only complication after 18\u2003months of follow\u2010up was transitory cushingoid aspect.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Tubulointerstitial nephritis and uveitis syndrome is a rare syndrome that is probably underdiagnosed in clinical practice. Co\u2010operation between ophthalmologists and nephrologists\/paediatricians is crucial for early diagnosis and instigation of treatment. Uveitis may occur before tubulointerstitial nephritis or the renal symptoms may be so mild that the patient is unaware of them. Therefore, ophthalmologists play an important role in the initial discovery of patients with TINU syndrome. Tubulointerstitial nephritis tends to be self\u2010limiting, whereas uveitis tends to relapse and recurrences tend to be more severe than the initial uveitis. Therefore, the patient must be ophthalmologically monitored very carefully.<\/jats:p>","DOI":"10.1111\/j.1755-3768.2008.01302.x","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T11:18:16Z","timestamp":1218539896000},"page":"676-679","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Tubulointerstitial nephritis and uveitis (TINU) syndrome: a case report and review of the literature"],"prefix":"10.1111","volume":"87","author":[{"given":"Veronica Holm","family":"Thomassen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Ring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Thaarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Baggesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(89)80212-4"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046096"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90390-3"},{"key":"e_1_2_4_5_1","first-page":"821","article-title":"Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity","volume":"8","author":"Gafter U","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_4_6_1","first-page":"373","article-title":"Tubulointerstitial nephritis and asymptomatic uveitis","volume":"13","author":"Gallego N","year":"2000","journal-title":"J Nephrol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00482-7"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.019"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050621"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00796.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.002"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00261-2"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.314"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045528"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90247-4"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90301-9"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1984.tb08400.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/jama.1977.03280090038018","article-title":"Nephropathia epidemica. 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