{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:17:33Z","timestamp":1790965053480,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Acta Ophthalmol. 2010: 88: e328\u2013e333<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the efficacy and safety of acupuncture for ocular symptoms, tear film stability and tear secretion in dry eye patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This is a randomized, patient\u2010assessor blinded, sham acupuncture controlled trial. Forty\u2010two participants with defined moderate to severe dry eye underwent acupuncture treatment three times a week for 3 weeks. Seventeen standard points (GV23; bilateral BL2, GB14, TE23, Ex1, ST1 and GB20; and unilateral SP3, LU9, LU10 and HT8 on the left for men and right for women) with \u2018<jats:italic>de qi<\/jats:italic>\u2019 manipulation for the verum acupuncture group and seventeen sham points of shallow penetration without other manipulation for the sham group were applied during the acupuncture treatment. Differences were measured using the ocular surface disease index (OSDI), the visual analogue scale (VAS) of ocular discomfort, the tear film break\u2010up time (BUT) and the Schimer I test with anaesthesia. In addition, adverse events were recorded.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were no statistically significant differences between results on the OSDI, VAS, BUT or Schimer I tests from baseline between the verum and sham acupuncture groups. However, results from the within\u2010group analysis showed that the OSDI and VAS in both groups and the BUT in the verum acupuncture group were significantly improved after 3 weeks of treatment. No adverse events were reported during this trial.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Both types of acupuncture improved signs and symptoms in dry\u2010eye patients after a 4\u2010week treatment. 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