{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:00:03Z","timestamp":1761292803549},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:00:00Z","timestamp":1303344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To assess the relationship between the prevalence and severity of conjunctivochalasis and pinguecula.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Cross\u2010sectional, consecutive case study conducted at the university hospital of University of Tokyo Graduate School of Medicine. A total of 1061 patients aged from 1 to 94\u2003years were enrolled. The grade and other parameters of conjunctivochalasis (classified into three locations: nasal, middle and temporal) and the grade of pinguecula located on the nasal or temporal conjunctiva were determined in all subjects. Patients were also divided into 5 or 10 age groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The severity of conjunctivochalasis affecting the nasal and temporal bulbar conjunctiva was significantly correlated with the grade of pinguecula located on the nasal and temporal conjunctiva in each age group (p\u2003&lt;\u20030.05). Pinguecula was independently associated with conjunctivochalasis (nasal: odds ratio [OR]\u2003=\u20031.44; temporal: OR\u2003=\u20031.43) after adjustment for age.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This was the first assessment of the relation between the grade of conjunctivochalasis and pinguecula in a large consecutive series of patients. Our results suggest that the prevalence and severity of conjunctivochalasis are related to the presence of pinguecula.<\/jats:p>","DOI":"10.1111\/j.1755-3768.2011.02161.x","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T11:43:37Z","timestamp":1303386217000},"page":"773-782","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Conjunctivochalasis: associations with pinguecula in a hospital\u2010based study"],"prefix":"10.1111","volume":"90","author":[{"given":"Tatsuya","family":"Mimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Obata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideharu","family":"Funatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Noma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Amano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"2506","article-title":"Tear fluid gelatinase B activity correlates with IL\u20101alpha concentration and fluorescein clearance in ocular rosacea","volume":"40","author":"Afonso AA","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000226365.64796.fb"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4314\/wajm.v24i2.28189","article-title":"Tear break\u2010up time in eyes with pterygia and pingueculae in Ibadan","volume":"24","author":"Balogun MM","year":"2005","journal-title":"West Afr J Med"},{"key":"e_1_2_6_5_1","first-page":"123","article-title":"Ueber faltenbildung der conjunctiva bulbi","volume":"66","author":"Braunschweig P","year":"1921","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.025460"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1186613"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31802e1e24"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199107000-00015"},{"key":"e_1_2_6_10_1","first-page":"121","article-title":"Stadium 4 der lidkantenparallelen conjunctivalen Falten\u2014ein klinisches Zeichen des fortgeschrittenen Sicca\u2010Syndroms","volume":"21","author":"H\u00f6h H","year":"1999","journal-title":"Contactologia"},{"key":"e_1_2_6_11_1","first-page":"802","article-title":"Lid\u2010parallel conjunctival folds are a sure diagnostic sign of dry eye","volume":"92","author":"H\u00f6h H","year":"1995","journal-title":"Ophthalmologe"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(42)93297-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(88)90071-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00140-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00037-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.120"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3181f91f2f"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71639-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790310.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265395"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.6.666"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280817"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100020037025"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.opx.0000232814.39651.fa"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.037"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-198608000-00012"},{"key":"e_1_2_6_28_1","unstructured":"World Health Organization(1985):Diabetes mellitus: report of WHO Study Group. 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