{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:42:57Z","timestamp":1770331377925,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To describe the distribution of basement membrane zone (BMZ) components in normal conjunctiva, conjunctiva of patients with glaucoma and normal skin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010five normal conjunctival biopsies and 16 conjunctival biopsies of patients with glaucoma under topical anti\u2010glaucomatous therapy were examined by immunohistochemistry. Antibodies were directed against laminin \u03b1 chains, laminin subchains \u03b11, \u03b12, \u03b13, \u03b21, \u03b23, \u03b31, \u03b32, \u03b33, kalinin, \u03b24\u2010integrin, and collagens IV and VII. Results were compared to the antigen distribution at the BMZ in normal skin.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The BMZ of skin stained positive for all antibodies tested. In contrast to skin, the BMZ of normal conjunctiva was negative for laminin subunits \u03b12, \u03b21, \u03b23, \u03b32 and \u03b33 in most or all specimens. Positive findings at the conjunctival BMZ of patients with glaucoma were comparable to normal conjunctiva for laminin \u03b1, \u03b11, \u03b23, \u03b31, \u03b33, laminin 5, \u03b24\u2010integrin, collagen IV and collagen VII. However, staining of the BMZ with antibodies to laminin \u03b21 (p\u2003=\u20030.002) and \u03b32 (p\u2003=\u20030.017) was seen in a significantly higher rate in glaucoma compared to controls.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Characteristic differences exist in the antigenicity of the BMZ in normal skin, normal conjunctiva and conjunctiva from patients with glaucoma, especially for laminin subchains. These differences may explain the variable ocular involvement in diseases of the BMZ. Moreover, they may explain the susceptibility of patients with glaucoma to develop mucous membrane pemphigoid\u2010like disease. Alterations in conjunctival BMZ in glaucoma may be induced by long\u2010term topical anti\u2010glaucoma medications including various preservation agents.<\/jats:p>","DOI":"10.1111\/j.1755-3768.2012.02481.x","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T17:25:20Z","timestamp":1345224320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differences in basement membrane zone components of normal conjunctiva, conjunctiva in glaucoma and normal skin"],"prefix":"10.1111","volume":"90","author":[{"given":"Elisabeth M.","family":"Messmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique M.","family":"Valet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anselm","family":"Kampik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.06.023"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090230060021"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1001\/archderm.1993.01680250060007","article-title":"Immune\u2010mediated subepithelial blistering diseases of mucous membranes. 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