{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:28:54Z","timestamp":1771046934692,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T00:00:00Z","timestamp":1351209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> SDOCT images, made with two different devices (3DOCT\u20101000, Topcon and Cirrus HD\u2010OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images was calculated based on a mathematical model described previously.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In total, forty\u2010eight eyes were included for pre\u2010 and postoperative cataract extraction measurements. OCT image quality significantly (p\u2003&lt;\u20030.001) improved postoperative and postoperative RNFL thickness was significantly (p\u2003&lt;\u20030.001) thicker in both groups of patients. The measurements using artificial filters showed a rather precise linear relation between change in filter induced optical density and change in RNFL thickness (<jats:italic>R<\/jats:italic>\u2003=\u20030.941, p\u2003&lt;\u20030.001 for 3DOCT\u20101000 and <jats:italic>R<\/jats:italic>\u2003=\u20030.785, p\u2003&lt;\u20030.001 for Cirrus HD\u2010OCT). For the patient groups, the relation was less marked, 3DOCT\u20101000 <jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub>\u2003=\u20030.697, p\u2003&lt;\u20030.03 and Cirrus HD\u2010OCT <jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub>\u2003=\u20030.444, p\u2003&lt;\u20030.03. The predictive potential based on the found linear relationship between OCT\u2010effective optical density of cataract and the cataract\u2010induced underestimation was however limited, and mean difference\u2003\u00b1\u2003SD between predicted and measured RNFL thickness were 1.68\u2003\u00b1\u20037.55 (3DOCT\u20101000) and 3.71\u2003\u00b1\u20032.97 (Cirrus HD\u2010OCT) micron.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A linear relationship exists between OCT\u2010effective optical density of cataract and underestimation of RNFL thickness measured with OCT. This finding holds promise to correct for cataract\u2010induced changes in RNFL measurements, but will differ for each type of OCT device.<\/jats:p>","DOI":"10.1111\/j.1755-3768.2012.02514.x","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T10:21:52Z","timestamp":1351246912000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography"],"prefix":"10.1111","volume":"91","author":[{"given":"Pauline H. B.","family":"Kok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J. T. P.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hille W.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilette","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka J. 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