{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:36:25Z","timestamp":1770438985769,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To determine whether indomethacin 0.1% eye drops are at least as effective as ketorolac 0.5% eye drops in treating ocular inflammation following cataract surgery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Prospective, multicenter, investigator\u2010masked, parallel\u2010group, randomized, active\u2010controlled clinical trial. Cataract patients were randomized in a 1:1 ratio to receive indomethacin or ketorolac administered QID for 3\u2003weeks beginning 1\u2003day before surgery. The primary end\u2010point was aqueous flare measured by laser flare meter at postoperative Days 1 and 7. Secondary end\u2010points included retinal thickness, slit lamp and funduscopic examinations and postsurgical pain ratings. Safety and tolerability were also assessed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 86 patients were included in the per protocol population (<jats:italic>n<\/jats:italic>\u2003=\u200343 per treatment group). Indomethacin was found non\u2010inferior to ketorolac for comparison of aqueous flare at postoperative Days 1 and 7 (Day 1: 95% CI: \u22122.37, 5.50; non\u2010inferiority upper margin, 15\u2003ph\/ms and Day 7: 95% CI: \u22127.83, \u22120.94; non\u2010inferiority upper margin, 8\u2003ph\/ms) and statistically better than ketorolac at Day 7 (p<jats:italic>\u2003=\u2003<\/jats:italic>0.013). There were no significant between\u2010group differences in aqueous flare and change from baseline in retinal thickness at postoperative Days 30 and 90. Indomethacin showed a higher subjective tolerance rating than ketorolac at postoperative Days 7 and 30 (p<jats:italic>\u2003<\/jats:italic>\u2264<jats:italic>\u2003<\/jats:italic>0.044).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Indomethacin 0.1% was at least as effective as ketorolac 0.5% at Day 1 and more effective than ketorolac 0.5% at Day 7 in treating ocular inflammation after uncomplicated cataract surgery. Indomethacin was better tolerated than ketorolac. There were no clinically meaningful safety concerns with either treatment.<\/jats:p>","DOI":"10.1111\/j.1755-3768.2012.02520.x","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T11:58:47Z","timestamp":1347451127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery"],"prefix":"10.1111","volume":"91","author":[{"given":"Michel","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Kodjikian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich E.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Zagorski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Allaire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(96)80161-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.55"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701537"},{"key":"e_1_2_6_5_1","first-page":"183","article-title":"Etude en double insu sur 3 groupes parall\u00e8les de deux formulations d\u2019indom\u00e9tacine \u00e0 0.1% et du diclof\u00e9nac \u00e0 0.1% dans la pr\u00e9vention et le contr\u00f4le de l\u2019inflammation apr\u00e8s chirurgie de la cataracte","volume":"20","author":"Arnaud B","year":"1997","journal-title":"J Fr Ophtalmol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000121704.40011.3d"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702460"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713680903288937"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767090-00004"},{"key":"e_1_2_6_10_1","first-page":"5","article-title":"A clinical comparison of two topical indomethacin formulations (0.1% solution versus 1% suspension) after cataract surgery","volume":"3","author":"Colin J","year":"1993","journal-title":"New Trends Ophthalmol"},{"key":"e_1_2_6_11_1","first-page":"177","article-title":"Safety and efficacy of loteprednol etabonate ophthalmic ointment 0.5% for the treatment of inflammation and pain following cataract surgery","volume":"5","author":"Comstock TL","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.12.029"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.09.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200102000-00002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01582.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-200201000-00003"},{"key":"e_1_2_6_17_1","first-page":"407","article-title":"The effect of ketorolac tromethamine in reducing postoperative inflammation: double\u2010mask parallel comparison with dexamethasone","volume":"21","author":"Flach AJ","year":"1989","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01896.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80485-3"},{"key":"e_1_2_6_20_1","first-page":"11","article-title":"Comparative study of two non\u2010steroidal anti\u2010inflammatory eyedrops, 0.1% indomethacin versus 0.1% diclofenac in pain control post photorefractive keratectomy","volume":"267","author":"Goes F","year":"1997","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00413-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01185-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.9.694"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.07.005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.09.024"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070050078035"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.08.043"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1998.760512.x"},{"key":"e_1_2_6_29_1","first-page":"201","article-title":"Etude de la prevention des reactions inflammatoires apres chirurgie de la cataracte par le Ketorolac tromethamine 0.5% versus Indocollyre 0.1%","volume":"8","author":"Le Rebeller MJ","year":"1994","journal-title":"Opthalmology"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1991.7.77"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00582-0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0908-2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225010-00004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050825"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90239-X"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(96)80160-X"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01077-X"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.1.99"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175922"},{"key":"e_1_2_6_40_1","first-page":"689","article-title":"Efficacy and tolerability of a combination of indomethacin and gentamicin for preventing inflammation after cataract surgery]","volume":"19","author":"Renard G","year":"1996","journal-title":"J Fr Ophtalmol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30641-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100060051031"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S4033"},{"key":"e_1_2_6_44_1","first-page":"367","article-title":"A review of the use of ketorolac tromethamine 0.4% in the treatment of post\u2010surgical inflammation following cataract and refractive surgery","volume":"1","author":"Sandoval HP","year":"2007","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_45_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/112067210301300605","article-title":"Effectiveness and tolerance of piroxicam 0.5% and diclofenac sodium 0.1% in controlling inflammation after cataract surgery","volume":"13","author":"Scuderi B","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140129002"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199511000-00018"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80484-1"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00543-1"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3681(13)80435-2"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000310180"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00203-9"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.01.033"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1755-3768.2012.02520.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1755-3768.2012.02520.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:05:56Z","timestamp":1698645956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1755-3768.2012.02520.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1755-3768.2012.02520.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1755-3768.2012.02520.x","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]},"assertion":[{"value":"2012-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}