{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:49:44Z","timestamp":1772160584720,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T00:00:00Z","timestamp":1355529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose:\u2002<\/jats:bold>\n                    To evaluate the efficacy and safety of deep sclerectomy in childhood glaucoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    A prospective cohort of 120 children presenting with glaucoma to King Abdul Aziz University Hospital (KAUH) was subjected to nonpenetrating deep sclerectomy surgery (NPDS). Eventually, 57 patients had macro perforation and converted to penetrating deep sclerectomy (PDS). Intra\u2010operative mitomycin C (MMC) 0.2\u2003mg\/ml was used in all patients. Pre\u2010 and postintervention glaucoma indices were assessed. Complete success rate (CSR) was identified as achieving an end\u2010point of intraocular pressure &lt;21 without any antiglaucoma medications. Data were analysed to compare pre\u2010 and postintervention changes and to compare both procedures.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    After follow\u2010up of 35.8 (34.5) months, NPDS procedure went smooth in 74 eyes of 63 patients. The complete success rate was 79.7%, whereas the overall success rate was 82.4%. Thirteen cases failed. The probability to survive was 74.6% after the 12th month. The mean intraocular pressure (IOP) went down to 11.5\u2003\u00b1\u20033.0\u2003mmHg compared to 31.9\u2003mmHg preoperatively. Comparing cases with NPDS to those with PDS, the magnitude of IOP reduction (15.8) was higher than that of the PDS (14.8); however, this difference was not statistically significant (p\u2003=\u20030.259). Apart from involuntary perforation of trabeculodescemetic window (TDW), neither intra\u2010operative nor early postoperative complications were observed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Deep sclerectomy in childhood glaucoma can effectively reduce the IOP, without the occurrence of serious complications that are commonly seen after trabeculotomy or combined trabeculotomy trabeculectomy.\n                  <\/jats:p>","DOI":"10.1111\/j.1755-3768.2012.02558.x","type":"journal-article","created":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T07:02:34Z","timestamp":1355554954000},"page":"65-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia"],"prefix":"10.1111","volume":"92","author":[{"given":"Saleh Ali","family":"Al\u2010Obeidan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam El\u2010Din Ahmed","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Salah","family":"Dewedar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Kestelyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Mousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"399","article-title":"Sturge\u2010Weber syndrome: management of glaucoma with combined trabeculotomy\u2010trabeculectomy","volume":"24","author":"Agarwal HC","year":"1993","journal-title":"Ophthalic surg"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.047761"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-008-9247-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(62)90388-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0415-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e318182ed9e"},{"key":"e_1_2_7_8_1","first-page":"188","article-title":"Primary trabeculectomy in congenital glaucoma","volume":"73","author":"Bruke JP","year":"1989","journal-title":"Br J Ophthalmolol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01077-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(08)70350-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.6.499"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01630.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3928\/01913913-20070701-04","article-title":"Causes of visual impairment in children: a study of 3,210 cases","volume":"44","author":"Haddad MA","year":"2007","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_7_14_1","first-page":"981","article-title":"Outcome of goniotomy in congenital glaucoma","volume":"20","author":"Kondo N","year":"2003","journal-title":"J. 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