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The seizure's latency and severity for each rat was recorded. Blood and brain hippocampal samples were collected for determination of serum neuron specific enolase (NSE), hippocampal Zn, interleukin\u20101 beta concentrations as well as hippocampal superoxide dismutase and caspase\u20103 activities. <jats:bold>Results:<\/jats:bold> The results of the current study demonstrated that pretreatment with high dose of Zn exacerbated pilocarpine\u2010induced seizures. Whereas, a medium dose of Zn and valproic acid either alone or in combination reduced the severity of pilocarpine\u2010induced limbic seizures and increased the latency to attain the forelimb clonus. Also both drugs, either alone or in combination, ameliorated all studied biochemical parameters with the exception of hippocampal Zn concentration, which was only significantly increased by pretreatment with Zn, either alone or in combination with valproic acid. <jats:bold>Conclusions:<\/jats:bold> The present study highlights the antiepileptic role that could be played by Zn, when given in appropriate doses.<\/jats:p>","DOI":"10.1111\/j.1755-5949.2011.00252.x","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T12:13:06Z","timestamp":1303992786000},"page":"327-333","source":"Crossref","is-referenced-by-count":24,"title":["Investigating the Role of Zinc in a Rat Model of Epilepsy"],"prefix":"10.1111","volume":"18","author":[{"given":"A. 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