{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:42:59Z","timestamp":1787920979981,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neuroscience &amp; Therapeutics"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Suicide is a complex and multicausal human behavior and also a great challenge for psychiatry. We review the evidence available concerning pharmacological prevention of suicide in bipolar disorder patients. Several clinical trials provide evidence that effective acute and long\u2010term treatment of bipolar depression provides a strong protection against suicide, suicide attempts, and probably against other complications of this disorder. Current major mood disorder is the most important risk factor of suicide, and bipolar II patients carry the highest risk. In bipolar patients suicidal behavior is most likely to occur during pure or mixed depressive episodes. Since bipolar disorder is a highly recurrent illness, adequate long\u2010term pharmacotherapy is needed to prevent suicidal behavior.<\/jats:p>","DOI":"10.1111\/j.1755-5949.2011.00261.x","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:19:47Z","timestamp":1312157987000},"page":"238-242","source":"Crossref","is-referenced-by-count":13,"title":["The Effect of Pharmacotherapy on Suicide Rates in Bipolar Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Zoltan","family":"Rihmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Gonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3280106868"},{"key":"e_1_2_10_3_2","first-page":"48","article-title":"Prediction and prevention of suicide in bipolar disorders","volume":"2","author":"Rihmer Z","year":"2005","journal-title":"Clin Neuropsychiatry"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01115.x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01066.x"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00553.x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01178.x"},{"issue":"2","key":"e_1_2_10_8_2","first-page":"63","article-title":"Suicide attempts in major affective disorder patients with comorbid substance use disorders","volume":"60","author":"Tondo L","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.7.1020"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/047084650X.ch3"},{"issue":"2","key":"e_1_2_10_11_2","first-page":"89","article-title":"Anticonvulsant therapy and suicide risk in affective disorders","volume":"60","author":"Goodwin FK","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_12_2","volume-title":"Manic\u2010depressive illness","author":"Goodwin FK","year":"1990"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0406"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.01.028"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00344.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15878"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0304"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01266.x"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.055798"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00377-9"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979553"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00302-6"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.05.019"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1467"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00464.x"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.014"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0605"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n1120c"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1281"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00672.x"},{"key":"e_1_2_10_31_2","first-page":"S371","article-title":"Placebo\u2010controlled study with acute and continuation phase of quetiapine in adults with bipolar depression (EMBOLDEN I)","volume":"18","author":"Young AH","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068683"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.04.003"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.05.018"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.05.017"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01563.x"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.014"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/047084650X.ch4"},{"key":"e_1_2_10_39_2","first-page":"49","article-title":"Treatment adherence in bipolar patients","volume":"1","author":"Colom F","year":"2002","journal-title":"Clin Appr Bipol Disord"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.145"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1160"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1755-5949.2011.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1755-5949.2011.00261.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1755-5949.2011.00261.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1755-5949.2011.00261.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1755-5949.2011.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:24:11Z","timestamp":1694305451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1755-5949.2011.00261.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1755-5949.2011.00261.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1755-5949.2011.00261.x","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}