{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:22:20Z","timestamp":1791404540529,"version":"4.3.3"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent antiinflammatory effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the effect of fucoidan treatment on inflammation\u2010mediated dopaminergic neuronal damage and its potential mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microglial activation and injury of dopaminergic neurons were induced by intranigral injection of lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>), and the effects of fucoidan treatment on animal behavior, microglial activation and survival ratio of dopaminergic neurons were investigated. We further observed the efficacy of fucoidan on tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and the production of reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) in LPS\u2010activated primary microglia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fucoidan significantly improved the behavioral manifestation, prevented the loss of dopaminergic neurons and inhibited the deleterious activation of microglia in the substantia nigra pars compacta of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010treated rats. Further <jats:italic>in vitro<\/jats:italic> experiments indicated that the excessive production of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> in LPS\u2010induced primary microglia were significantly inhibited by fucoidan administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to demonstrate that fucoidan possesses neuroprotective effects on injured dopaminergic neurons in a <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced animal model of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease. The mechanisms underlying these effects may include its potent down\u2010regulation of intracellular <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and subsequent proinflammatory cytokine release in <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010activated microglia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1755-5949.2012.00372.x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T12:17:06Z","timestamp":1348575426000},"page":"827-833","source":"Crossref","is-referenced-by-count":87,"title":["Fucoidan Protects against Lipopolysaccharide\u2010Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia"],"prefix":"10.1111","volume":"18","author":[{"given":"Yan\u2010Qiu","family":"Cui","sequence":"first","affiliation":[{"name":"Capital Medical University Yanjing Medical College Beijing China"},{"name":"Key laboratory of Neurodegenerative Diseases of the Ministry of Education Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"Key laboratory of Neurodegenerative Diseases of the Ministry of Education Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Oceanology, Chinese Academy of Sciences Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Key laboratory of Neurodegenerative Diseases of the Ministry of Education Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0428-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation\u2010mediated neurodegeneration: multiple triggers with a common mechanism","volume":"76","author":"Bloke ML","year":"2005","journal-title":"Prog Neurobiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwg058"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04111.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.03.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.04.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05314.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40634"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200305230-00037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.02.058"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10253"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2038"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00928.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6361"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1755-5949.2012.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1755-5949.2012.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:29:59Z","timestamp":1695493799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1755-5949.2012.00372.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1755-5949.2012.00372.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1755-5949.2012.00372.x","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]}}}