{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:31:56Z","timestamp":1791322316329,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T00:00:00Z","timestamp":1329091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To examine the prevalence of sicca symptoms and secondary S<\/jats:styled-content>j\u00f6gren's syndrome (sSS<\/jats:styled-content>) in rheumatoid arthritis (RA<\/jats:styled-content>) patients, and the impact of sSS<\/jats:styled-content> on disease activity and treatment profile in RA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Three hundred and seven RA<\/jats:styled-content> patients responding positive to at least one of the questions in a questionnaire about sicca symptoms, were examined by S<\/jats:styled-content>chirmer I<\/jats:styled-content> test for tear production, and unstimulated whole saliva collection (USWC<\/jats:styled-content>). Secondary S<\/jats:styled-content>j\u00f6gren's syndrome was defined by at least one subjective sicca symptom, in addition to a positive S<\/jats:styled-content>chirmer I<\/jats:styled-content> test and positive USWC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 307 RA<\/jats:styled-content> patients, 86 (28%) responded positive to at least one question about sicca symptoms, and 11 patients were positive for both S<\/jats:styled-content>chirmer I<\/jats:styled-content> and USWC<\/jats:styled-content> tests, giving a minimum prevalence of sSS<\/jats:styled-content> at 3.6%. There were no differences in RA<\/jats:styled-content> patients with and without sSS<\/jats:styled-content> regarding age, sex, disease duration, disease activity score (DAS<\/jats:styled-content>\u201028) and seropositivity for anti\u2010cyclic citrullinated protein. RA<\/jats:styled-content> patients with sSS<\/jats:styled-content> had a tendency for higher numbers of tender and swollen joints and pain. None of the RA<\/jats:styled-content> patients treated with tumor necrosis factor (TNF<\/jats:styled-content>) inhibitors had sSS<\/jats:styled-content>, compared to 22% of the rest of the RA<\/jats:styled-content> population studied. The treatment of the RA<\/jats:styled-content> patients with and without sSS<\/jats:styled-content> was not different.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Among the 307 RA<\/jats:styled-content> patients, 28% had at least one sicca symptom. The estimated minimum of prevalence of sSS<\/jats:styled-content> in 307 RA<\/jats:styled-content> patients was 3.6%. Secondary S<\/jats:styled-content>j\u00f6gren's syndrome was not found in RA<\/jats:styled-content> patients treated with biologics such as TNF<\/jats:styled-content> blockers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1756-185x.2012.01717.x","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T08:07:25Z","timestamp":1329120445000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["A study of the prevalence of sicca symptoms and secondary S<\/scp>j\u00f6gren's syndrome in patients with rheumatoid arthritis, and its association to disease activity and treatment profile"],"prefix":"10.1111","volume":"15","author":[{"given":"Hans\u2010Jacob","family":"Haga","sequence":"first","affiliation":[{"name":"Aalborg University Esbjerg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Naderi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Sydvestjysk Sygehus Esbjerg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Martin","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Urology The National Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Peen","sequence":"additional","affiliation":[{"name":"Aalborg University Esbjerg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1736","volume-title":"Arthritis and Allied Conditions. 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