{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:09:14Z","timestamp":1759421354339},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the clinical profile of patients with plasma cell dyscrasias presenting with inflammatory arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective analysis was performed on clinical, laboratory and imaging data of patients who presented with inflammatory arthritis between <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2009 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2010 and were subsequently diagnosed as having plasma cell dyscrasias. Six out of 630 patients presenting with inflammatory arthritis were identified. The demographic, clinical and laboratory characteristics of these patients were analyzed. The diagnosis of monoclonal gammopathy was based on protein electrophoresis, immunoelectrophoresis and bone marrow biopsy. The outcomes of the treatments were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients had monoclonal gammopathy of unknown significance and two patients had multiple myeloma. Mean age of the patients was 65\u00a0years (range 59\u201374). Three patients presented with oligoarticular arthritis, two with symmetrical polyarticular joint pains and one with fleeting periarticular pains. Wrist and shoulder were the most commonly involved joints. Three patients had carpal tunnel syndrome. Five patients were seronegative for both rheumatoid factor and anti\u2010cyclic citrullinated peptide antibodies. Mean erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) was high in all patients (range: 82\u2013120\u00a0mm\/h with a mean of 99.6\u00a0mm\/h). Arthritis improved with chemotherapy in patients with multiple myeloma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Occurrence of inflammatory arthritis with plasma dyscrasias is more than a chance association. Plasma cell dyscrasias should be ruled out in any elderly patient presenting with atypical arthritis with disproportionately high <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>, high creatinine and hyperglobulinemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1756-185x.2012.01727.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T01:21:06Z","timestamp":1340068866000},"page":"336-339","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monoclonal gammopathies presenting as inflammatory arthritis: uncommon but important \u2013 a case series"],"prefix":"10.1111","volume":"15","author":[{"given":"Nagaraj","family":"Srinivasulu","sequence":"first","affiliation":[{"name":"Department of Rheumatology PD Hinduja National Hospital and MRC Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology PD Hinduja National Hospital and MRC Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Rheumatology PD Hinduja National Hospital and MRC Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.3.241"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341220"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.Suppl_1.34"},{"key":"e_1_2_4_5_1","first-page":"69","article-title":"The association of rheumatoid arthritis with plasma cell neoplasm","volume":"12","author":"Goldcnberg GJ","year":"1996","journal-title":"Arthritis Rheum"},{"issue":"7","key":"e_1_2_4_6_1","first-page":"1473","article-title":"Amyloid arthropathy in the course of multiple myeloma","volume":"29","author":"Fautrel B","year":"2002","journal-title":"J Rheumtol"},{"key":"e_1_2_4_7_1","first-page":"417","article-title":"A study of amyloid arthropathy in multiple myeloma","volume":"200","author":"Hickling P","year":"1981","journal-title":"Q J Med"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.1.81-a"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-84"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90122-9"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.5.290"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197211000-00003"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02591663"},{"key":"e_1_2_4_14_1","first-page":"2175","article-title":"Tumoral joint involvement in multiple myeloma and Waldenstr\u00f6ms macroglobulinaemia \u2013 report of 4 cases","volume":"23","author":"Roux S","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90162-9"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1756-185X.2012.01727.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1756-185X.2012.01727.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:22:50Z","timestamp":1698772970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1756-185X.2012.01727.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1756-185X.2012.01727.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1756-185x.2012.01727.x","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"2012-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}