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The Assessment in Spondylarthritis International Society recommendations for the management of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> have been modified so that patients with non\u2010radiographic spondyloarthritis (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) can now be considered for biological therapy. The \u2018older\u2019 anti\u2010tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>) continued to be effective in longer\u2010term studies. Studies with longer duration of follow\u2010up have shown that some patients with pre\u2010radiographic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> entered into prolonged drug\u2010free remission. It is likely that in the foreseeable future, more <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients will be treated with biological therapies at an earlier stage of the disease. New biologic therapies, golimumab and secukinumab, are looking promising in improving the signs and symptoms of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>, at least in the short\u2010term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Longer\u2010term studies of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients treated with infliximab, etanercept and adalimumab continued to show a good clinical response. There is a need for more long\u2010term studies to examine the longitudinal efficacy of golimumab and secukinumab in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1756-185x.2012.01765.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T05:04:49Z","timestamp":1341810289000},"page":"445-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Update on biologic therapies in ankylosing spondylitis: a literature review"],"prefix":"10.1111","volume":"15","author":[{"given":"Leslie","family":"Goh","sequence":"first","affiliation":[{"name":"Department of Rheumatology Musgrove Park Hospital  Taunton Somerset UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ash","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.766"},{"key":"e_1_2_10_4_1","first-page":"688","article-title":"The natural history of ankylosing spondylitis. 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