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The present report examines published studies that have associated hypercholesterolemia with DO to determine the grounds on which such studies were based. According to our analysis, OAB and DO are closely related with hypercholesterolemia. Furthermore, DO and OAB may be affected not just by a single factor like hypercholesterolemia, but rather by all components of metabolic syndrome. Several mechanisms, including autonomic overactivity, artherosclerosis, ischemic change, alteration of nitric oxide synthase (NOS)\/NO system and increased Rho\u2010kinase activity may have a role in the relationship between OAB and hypercholesterolemia. Further studies are warranted, however, to evaluate more about the pathophysiology of OAB.<\/jats:p>","DOI":"10.1111\/j.1757-5672.2011.00124.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T06:53:02Z","timestamp":1332139982000},"page":"16-20","source":"Crossref","is-referenced-by-count":1,"title":["Detrusor Overactivity in Hyperchoelsterolemia Rats"],"prefix":"10.1111","volume":"4","author":[{"given":"Hwancheol","family":"SON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Suk","family":"CHOI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Seung","family":"PAICK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won 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