{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T22:41:39Z","timestamp":1694558499230},"reference-count":50,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Regenerative medicine based on tissue engineering and\/or stem cell therapy techniques has the potential to improve irreversibly damaged tissues. Surgical injury to the lower urinary tract can occur as a result of radical prostatectomy or bladder neck surgery. Regeneration of urethral sphincters could be an effective treatment for post\u2010surgical intrinsic sphincter deficiency (ISD)\u2010related urinary incontinence. The replacement, enhancement, and\/or recovery the urethral sphincter striated and smooth muscles could increase urethral closure pressure to help patients regain continence. Stem cells from muscle\u2010derived satellite or adipose\u2010derived mesenchymal cells provide temporary improvement in urethral closure pressure but do not reconstruct the muscle layer structures. Our strategy to accomplish regeneration of urethral sphincters is the utilization of autologous bone marrow\u2010derived cells. We have developed a freeze injury model of ISD in rabbits. Freezing of the urinary sphincter causes loss of the majority of striated and smooth muscle cells, and causes a significant decrease in leak point pressure. In this review, we show that the autologous bone marrow\u2010derived cells implanted within the freeze\u2010injured sphincters differentiate into striated or smooth muscle cells. These cells then develop to reconstitute muscle layer structures within the sphincter. Furthermore, the leak point pressure of cell\u2010implanted rabbits is significantly higher than that of cell\u2010free injected controls. We conclude that implantation of autologous bone marrow\u2010derived cells could be an effective treatment for human post\u2010surgical ISD\u2010related urinary incontinence.<\/jats:p>","DOI":"10.1111\/j.1757-5672.2011.00136.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T06:53:02Z","timestamp":1332139982000},"page":"87-94","source":"Crossref","is-referenced-by-count":0,"title":["Autologous Bone Marrow\u2010Derived Cells Regenerate Urethral Sphincters"],"prefix":"10.1111","volume":"4","author":[{"given":"Tetsuya","family":"IMAMURA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"ISHIZUKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"NISHIZAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368908784153850"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0038"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0478"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2010.02471.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0553-9"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0170"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.12.031"},{"key":"e_1_2_12_9_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1757-5672.2010.00067.x","article-title":"Rat bladders augmented with a novel bovine pericardium\u2010derived biomaterial reconstruct functional tissue structures.","volume":"2","author":"Mimura Y","year":"2010","journal-title":"LUTS"},{"key":"e_1_2_12_10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1757-5672.2010.00066.x","article-title":"Bone marrow\u2010derived cells implanted into freeze\u2010injured urinary bladders reconstructs functional smooth muscle layers.","volume":"2","author":"Imamura T","year":"2010","journal-title":"LUTS"},{"key":"e_1_2_12_11_2","first-page":"3","article-title":"Prevalence and natural history of female incontinence.","volume":"32","author":"Hampel C","year":"1997","journal-title":"Eur Urol"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000137874.84862.94"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-4806(09)73187-0"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.01.009"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01269.x"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-004-1231-z"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.10.029"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06002.x"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02558-X"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.048"},{"key":"e_1_2_12_21_2","first-page":"5","article-title":"Current role of injectable agents for female stress urinary incontinence.","volume":"13","author":"Herschorn S.","year":"2006","journal-title":"Can J Urol"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-009-0062-3"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-002-0086-4"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e32833a4420"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00321.x"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042307-200207000-00012"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0935"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.09.021"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.09137"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00679-4"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.035"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-012-2280-7"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0269-9"},{"key":"e_1_2_12_34_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/cell.2010.0105","article-title":"Inhibition of fibroblast differentiation of muscle\u2010derived stem cells in cell implantation treatment of stress urinary incontinence.","volume":"15","author":"Wang Y","year":"2011","journal-title":"Cell Reprogram"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903350265"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02795.x"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2011.04.003"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04610.x"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9645"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3070"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425405"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme.09.32"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00749.x"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.165837"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-141"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3314"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-6-453"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10173"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20229"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000090396.71097.C2"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1757-5672.2011.00136.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1757-5672.2011.00136.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:54:31Z","timestamp":1694469271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1757-5672.2011.00136.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":50,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1757-5672.2011.00136.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1757-5672.2011.00136.x","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}