{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:52:32Z","timestamp":1698727952061},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> To evaluate the effects of propiverine and its active metabolites (M\u20101 and M\u20102) on bladder function through modulation of afferent activity in rats.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Cystometry was performed in urethane anesthetized female rats. We examined the effects of intravesical administration of propiverine, M\u20101 and M\u20102 on bladder overactivity induced by oxotremorine\u2010M (Oxo\u2010M; non\u2010selective mAChR agonist).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Intravesical administration of Oxo\u2010M (200 \u00b5M) elicited bladder overactivity as evidenced by decreased intercontraction interval (ICI) and pressure threshold (PT) without changing maximum voiding pressure or baseline pressure. These effects were blocked by intravesical administration of propiverine (30 \u00b5M) or M\u20102 (300 \u00b5M). Intravesical administration of M\u20101 (30 \u00b5M) alone increased ICI and PT, but did not prevent Oxo\u2010M\u2010induced decreases in ICI and PT.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These results suggest that propiverine and M\u20102 have anticholinergic effects on bladder afferent activity and that M\u20101 has an inhibitory effect through the mechanism other than muscarinic receptor modulation. Thus, clinical benefits of propiverine in patients with overactive bladder could be mediated by multiple actions of propiverine and its active metabolites.<\/jats:p>","DOI":"10.1111\/j.1757-5672.2012.00152.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T03:25:49Z","timestamp":1334719549000},"page":"150-153","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of Bladder Afferent Activity by Propiverine and its Active Metabolites (M\u20101 and M\u20102) in Rats"],"prefix":"10.1111","volume":"4","author":[{"given":"Yoshihiro","family":"MATSUMOTO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"TORIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"NANRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"KINIWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"HIRAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"YOSHIMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09050.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02732.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.033233"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3999\/jscpt.21.555"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.94.145"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.94.173"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.07.005"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.06.088"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4694-07.2008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.12.013"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.02.046"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90631-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130021"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.04.002"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-006-0103-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.304"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000049903.60057.4b"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1757-5672.2012.00152.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1757-5672.2012.00152.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:40:18Z","timestamp":1698655218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1757-5672.2012.00152.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,17]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1757-5672.2012.00152.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1757-5672.2012.00152.x","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,17]]}}}