{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:21:23Z","timestamp":1765959683465},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T00:00:00Z","timestamp":1347580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Single\u2010incision laparoscopic cholecystectomy (SILC<\/jats:styled-content>) is increasingly practiced, but there have been no well\u2010powered randomized trials investigating the technique. This non\u2010inferiority trial aims to compare SILC<\/jats:styled-content> with conventional four\u2010port laparoscopic cholecystectomy (LC<\/jats:styled-content>) with postoperative pain as the primary endpoint.<\/jats:p><\/jats:sec>Methods<\/jats:title>We aim to randomize 100 patients into equal arms of SILC<\/jats:styled-content> or LC<\/jats:styled-content>. Exclusion criteria were: (i) acute cholecystitis; (ii) an ASA<\/jats:styled-content> score of 3 or above; (iii) bleeding disorders; or (iv) previous upper abdominal surgery. Patients and postoperative assessors were blinded to the procedure received. The site and severity of pain was compared based on the visual analogue scale at 4 hours, 24 hours and 14 days postoperatively; non\u2010inferiority was assumed when the lower boundary of the 95% confidence interval of the difference was above \u22121, and superiority when P<\/jats:italic>\u2009\u2264\u20090.05.<\/jats:p><\/jats:sec>Results<\/jats:title>We recruited 24 SILC<\/jats:styled-content> and 26 LC<\/jats:styled-content> patients. There were no conversions to open cholecystectomy or from SILC<\/jats:styled-content> to LC<\/jats:styled-content>. SILC<\/jats:styled-content> was non\u2010inferior for pain at umbilical sites at rest and at extra\u2010umbilical sites at all times. At 24 hours postoperatively, SILC<\/jats:styled-content> was associated with significantly less pain at extra\u2010umbilical sites (rest: P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002; movement: P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.004). There were no incidents of biliary injury or retained gallstones. Of the 24 SILC<\/jats:styled-content> patients, 12.5% had postoperative complications (vomiting, mild fluid overload, wound infection) compared with 0% of LC<\/jats:styled-content> patients (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.110); all complications resolved with conservative management. Operating time, analgesic use, return to function, and overall satisfaction did not differ significantly between the two groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>SILC<\/jats:styled-content> is associated with reduced pain and is feasible in routine surgical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1758-5910.2012.00154.x","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T03:32:02Z","timestamp":1347679922000},"page":"14-20","source":"Crossref","is-referenced-by-count":13,"title":["Interim report: A randomized controlled trial comparing postoperative pain in single\u2010incision laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy"],"prefix":"10.1111","volume":"6","author":[{"given":"Stephen Kin Yong","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Surgery National University Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shen","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shridhar Ganpathi","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Bin Syed Buhari","family":"Shaik","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Lomanto","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital 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