{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:14:33Z","timestamp":1760188473810,"version":"3.32.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T00:00:00Z","timestamp":1109116800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>Nonarteritic acute anterior ischemic optic neuropathy (NAION) is a disabling disease which impairs visual function. It is presumed to result from disturbances of microcirculation in the anterior portion of the optic nerve head due to hemodynamic factors derived from excessive blood viscosity, or restriction of the vasal lumen in hypertensive, hypercholesterolemic, diabetic patients. We aimed to determine whether acute reduction of plasma fibrinogen and serum low\u2010density lipoprotein (LDL) cholesterol is effective for treatment of NAION. We recruited 11 patients (7 females, 4 males) with a mean age of 57.2\u2003\u00b1\u200319.6\u2003years. All except one of them presented risk factors for atherosclerosis. The mean values of LDL\u2010cholesterol and fibrinogen before treatment were 144\u2003\u00b1\u200332\u2003mg\/dL and 341\u2003\u00b1\u200380\u2003mg\/dL, respectively. All were treated with standard therapy (prednisone, salicylate, pentoxiphyllin) and underwent three sessions of LDL\u2010apheresis (HELP system\u2014B Braun) that can reduce plasma LDL\u2010cholesterol and fibrinogen by more than 50% in a very short time. In all patients we observed a drastic reduction of LDL cholesterol and fibrinogen and a clear improvement in the visual functional data. In fact, mean values of corrected vision increased from 3.7\/10\u2003\u00b1\u20033\/10 to 7.9\/10\u2003\u00b1\u20032.2\/10 (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) after the third session, while the scotomatous portion of the visual field regressed after the first session, and in 5 patients further regressed after the third session. This improvement had remained stable after 3\u2003months. Thanks to it's effect of antagonizing hemorheologic disorders of the ocular microcirculation, fibrinogen\/LDL\u2010apheresis seems to be an efficacious treatment of NAION.<\/jats:p>","DOI":"10.1111\/j.1774-9987.2005.00205.x","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T15:01:32Z","timestamp":1109170892000},"page":"53-58","source":"Crossref","is-referenced-by-count":18,"title":["LDL\u2010Apheresis Accelerates the Recovery of Nonarteritic Acute Anterior Ischemic Optic Neuropathy"],"prefix":"10.1111","volume":"9","author":[{"given":"Alfonso","family":"Ramunni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Giancipoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Guerriero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Lapenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Saracino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Saliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Sborgia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Coratelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70999-7"},{"key":"e_1_2_6_3_2","first-page":"2202","article-title":"[Acute anterior, ischemic optic neuropathy]","volume":"51","author":"Vignal\u2010Clermont C.","year":"2001","journal-title":"Rev Prat"},{"key":"e_1_2_6_4_2","first-page":"171","article-title":"Ischaemic optic neuropathy","volume":"48","author":"Hayreh SS.","year":"2000","journal-title":"Indian J Ophthalmol"},{"key":"e_1_2_6_5_2","first-page":"83","article-title":"Ischemic optic neuropathies","volume":"14","author":"Arnold AC.","year":"2001","journal-title":"J Neuroophthalmol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199406000-00002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200306000-00012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160573008"},{"key":"e_1_2_6_9_2","first-page":"196","article-title":"Hemorrheologic analyses of anterior ischemic optic neuropathy","volume":"34","author":"Wang R","year":"1998","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2001.00368.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2362.1989.tb00192.x","article-title":"Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin\u2010induced extracorporeal LDL precipitation (HELP)","volume":"19","author":"Schuff\u2010Werner P","year":"1989","journal-title":"Eur J Clin Invest"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-0968.2001.00289.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.76"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139880302600312"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139880402700410"},{"key":"e_1_2_6_16_2","first-page":"354","article-title":"Risk factors and clinical fluorescein angiography findings in anterior ischemic optic neuropathy","volume":"93","author":"Sprau CW","year":"1996","journal-title":"Ophthalmologe"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408233110804"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03400090067035"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711263172201"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3233\/BIR-1977-145-605","article-title":"Plasma viscosity in 615 subjects. 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