{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:40:10Z","timestamp":1697056810336},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The objective of our study was to assess the influence of residual renal function and other factors on epoetin requirements in chronic peritoneal dialysis patients. Fifty\u2010one stable patients (mean age\u2003\u00b1\u2003SD: 52\u2003\u00b1\u200313\u2003years; 20 women) without recent bleeding, bone marrow disease or malignancy were recruited in four Slovenian centers. The target hemoglobin was above 110\u2003g\/L. The peritoneal equilibration test results and relevant clinical and laboratory parameters were recorded. The epoetin resistance index was expressed as a weekly epoetin dose\/body weight\/hemoglobin concentration. Twenty\u2010four percent of the patients did not need epoetin treatment, the rest were treated with epoetin\u2010beta in a dose of 70\u2003\u00b1\u200356\u2003U\/kg per week s.c.; the hemoglobin concentration was 124\u2003\u00b1\u200315\u2003g\/L. Ferritin &gt;100\u2003\u00b5g\/L and transferrin saturation &gt;20% fulfilled 63% of patients whose epoetin resistance index was not significantly lower (0.43\u2003\u00b1\u20030.5\u2003U\/kg per week per g\/L vs 0.6\u2003\u00b1\u20030.72\u2003U\/kg per week per g\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.502). No difference was found between diabetic and non\u2010diabetic patients. Treatment with angiotensin system antagonists, but not with aluminum phosphate binders, was associated with increased epoetin resistance index (0.56\u2003\u00b1\u20030.59 vs 0.3\u2003\u00b1\u20030.4\u2003U\/kg per week per g\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.038). No correlation between epoetin resistance index and residual glomerular filtration rate was found (<jats:italic>r\u2003=<\/jats:italic>\u2003\u22120.2, <jats:italic>P<\/jats:italic>\u2003=\u20030.173). A multiple linear regression analysis showed C\u2010reactive protein, intact parathormone level, female sex and treatment with angiotensin system antagonists to be the independent predictors influencing epoetin resistance index. Our results show that systemic inflammation, secondary hyperparathyroidism and angiotensin system antagonist treatment are the most important modifiable parameters affecting epoetin requirements in stable peritoneal dialysis patients.<\/jats:p>","DOI":"10.1111\/j.1774-9987.2005.00260.x","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:12:47Z","timestamp":1119373967000},"page":"228-232","source":"Crossref","is-referenced-by-count":6,"title":["Epoetin Responsiveness in Peritoneal Dialysis Patients: A Multi\u2010center Slovenian Study"],"prefix":"10.1111","volume":"9","author":[{"given":"Jernej","family":"Pajek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Bu\u010dar\u2010Pajek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Grego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Gu\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastjan","family":"Bevc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ekart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Vujkovac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polona","family":"Golob\u2010Kosmina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aljo\u0161a","family":"Kandus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej F","family":"Bren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,21]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"200","article-title":"The use of subcutaneous erythropoietin in CAPD","volume":"33","author":"Piraino B","year":"1990","journal-title":"Clin Nephrol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh1032"},{"key":"e_1_2_7_4_2","first-page":"697","article-title":"Erythropoietin requirements: a comparative multicenter study between peritoneal dialysis and hemodialysis","volume":"16","author":"Coronel F","year":"2003","journal-title":"J Nephrol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000102475.94185.54"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.7.1763"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000016440.52271.F7"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000013394"},{"key":"e_1_2_7_9_2","first-page":"111","article-title":"Erythropoietin resistance in patients on continuous ambulatory peritoneal dialysis","volume":"20","author":"Nakamoto H","year":"2004","journal-title":"Adv Perit Dial"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2001.16.2.110"},{"key":"e_1_2_7_11_2","first-page":"130","article-title":"Diabetic patients on peritoneal dialysis need less erythropoietin to maintain adequate hemoglobin","volume":"17","author":"Page DE","year":"2001","journal-title":"Adv Perit Dial"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045514"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(88)80123-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.suppl_4.15"},{"key":"e_1_2_7_15_2","first-page":"137","article-title":"Does residual renal function decline more rapidly in hemodialysis than in peritoneal dialysis? 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