{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:29:03Z","timestamp":1793201343780,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of this study was to determine the effects of bleaching on the structure of the enamel layer of teeth and the potential of the commercial bioactive glass NovaMin\u00ae in two different toothpastes to remineralize such regions of the enamel. Three aspects were considered: the extent and nature of the alterations in the enamel after application of the bleaching agents; the extent of remineralization after application of two commercial toothpastes containing bioactive glass; and whether or not there were differences between the toothpastes in terms of their effectiveness in promoting remineralization.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Bleaching agent based on 16% carbamide peroxide was applied to the enamel surface of freshly extracted human molars for 8\u2003minutes, once a day for 7\u2003days. After the bleaching cycles, the enamel surface was analysed by SEM and EDX.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The results obtained in the study lead to the conclusion that application of 16% carbamide peroxide causes distinct morphological changes to the enamel surface which vary from mild to severe. Subsequent treatment with either of the toothpastes containing the bioactive glass NovaMin\u00ae resulted in the formation of a protective layer on the enamel surface, consisting of bioactive glass deposits, with only slight differences between the two brands. Application of these dentifrices also caused increases in the Ca and P content of the enamel layer, returning it to that of undamaged enamel.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Remineralizing toothpastes should be used after bleaching, in order to repair any damage to the mineral tissue caused by these procedures.<\/jats:p>","DOI":"10.1111\/j.1834-7819.2011.01323.x","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T05:18:06Z","timestamp":1308028686000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Prevention of enamel demineralization after tooth bleaching by bioactive glass incorporated into toothpaste"],"prefix":"10.1111","volume":"56","author":[{"given":"E","family":"Gjorgievska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JW","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2007.09.008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2006.02.002"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2000.00510.x"},{"key":"e_1_2_7_5_2","first-page":"775","article-title":"Nightguard vital bleaching: effects of various solutions on enamel surface texture and color","volume":"22","author":"Haywood VB","year":"1991","journal-title":"Quintessence Int"},{"key":"e_1_2_7_6_2","first-page":"53","article-title":"Effects of hydrogen peroxide\u2010containing bleaching agents on the morphology of human enamel","volume":"27","author":"Ernst CP","year":"1996","journal-title":"Quintessence Int"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(85)80070-6"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572005000200021"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(92)90600-F"},{"key":"e_1_2_7_10_2","first-page":"39","article-title":"Characterization of enamel exposed to 10% carbamide peroxide bleaching agents","volume":"24","author":"Shannon H","year":"1993","journal-title":"Quintessence Int"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(99)00006-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.03.008"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0085328204044538"},{"key":"e_1_2_7_14_2","article-title":"Quantitative analysis of tubule occlusion using NovaMin\u00ae (sodium calcium phosphosilicate)","volume":"83","author":"Jennings DT","year":"2004","journal-title":"J Dent Res"},{"key":"e_1_2_7_15_2","volume-title":"Bioceramics 10, Proceedings of the 10th International Symposium on Ceramics in Medicine","author":"Litkowski LJ","year":"1997"},{"key":"e_1_2_7_16_2","article-title":"Efficacy of dentifrice containing bioactive glass (NovaMin\u00ae) on dentine hypersensitivity","volume":"83","author":"Du MQ","year":"2004","journal-title":"J Dent Res"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1142\/2028","volume-title":"An introduction to bioceramics","author":"Hench LL","year":"1993"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820250808"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014075320987"},{"key":"e_1_2_7_20_2","article-title":"Enamel remineralization potential of two dentifrices based on CPP\u2010ACP and Novamin\u00ae (Calcium sodium\u2010phosphosilicate)","author":"Gjorgievska E","journal-title":"Acta Odontol Latinoam"},{"key":"e_1_2_7_21_2","first-page":"84","article-title":"A scanning electron microscope study of the long\u2010term effect of bleaching agents on the enamel surface in vivo","volume":"46","author":"Bitter NC","year":"1998","journal-title":"Gen Dent"},{"key":"e_1_2_7_22_2","first-page":"29","article-title":"Effect of mouthguard bleaching on enamel surface","volume":"8","author":"Ben\u2010Amar A","year":"1995","journal-title":"Am J Dent"},{"key":"e_1_2_7_23_2","first-page":"117","article-title":"[Effects of two bleaching agents on the enamel surface. 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