{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:43:00Z","timestamp":1760888580432},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T00:00:00Z","timestamp":1317600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian Dental Journal"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Previous studies have demonstrated variable effects on systemic inflammatory and immune responses following improved periodontal health. This study examined changes in serum levels of the inflammatory mediators IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1 and sICAM\u20101, and antibodies to <jats:italic>Porphyromonas gingivalis,<\/jats:italic> human heat shock protein (hHSP) 60 and <jats:italic>P. gingivalis<\/jats:italic> GroEL following improvement in periodontal health in high cardiovascular (CV) risk and low CV\u2010risk patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients retrospectively selected from a longitudinal study, had undergone yearly periodontal examinations and peripheral blood collections. They had demonstrated a quantifiable improvement in periodontal health (&gt;60% reduction in number of sites with probing depth \u22654\u2003mm from the baseline visit) and could be classified as either high CV\u2010risk (\u22656 classical risk factors, n\u2003=\u200313) or low CV\u2010risk (\u22641 classical risk factor, n\u2003=\u200314). Serum levels of the cytokines and antibodies were measured using ELISA.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> For sICAM\u20101 and anti\u2010<jats:italic>P. gingivalis<\/jats:italic> GroEL and anti\u2010hHSP60 antibodies, most patients recorded decreased levels. Reductions in serum sICAM\u20101 levels were more notable in low CV\u2010risk patients (p\u2003=\u20030.006); and reductions in levels of anti\u2010<jats:italic>P. gingivalis<\/jats:italic> GroEL and anti\u2010hHSP60 antibodies (p\u2003=\u20030.001 and 0.009 respectively) were more notable in high CV\u2010risk patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This study found that subsequent to improved periodontal health, the anti\u2010HSP (HSP60 and GroEL) antibody response was reduced, particularly for high CV\u2010risk patients. sICAM\u20101 levels were also lowered, more so for low CV\u2010risk patients.<\/jats:p>","DOI":"10.1111\/j.1834-7819.2011.01363.x","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T06:07:52Z","timestamp":1317622072000},"page":"352-357","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved periodontal health and cardiovascular 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