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Over the next two years the BRONJ was treated conservatively but gradually became more symptomatic. About three years after her last dose of zolodronic acid with her symptoms increasing, she underwent radical surgical excision of all diseased bone and flap reconstruction. The patient is now six months postoperative and symptom free.<\/jats:p>","DOI":"10.1111\/j.1834-7819.2012.01675.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T18:08:25Z","timestamp":1332871705000},"page":"227-230","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Radical surgical treatment of bisphosphonate related osteonecrosis of the jaw"],"prefix":"10.1111","volume":"57","author":[{"given":"I","family":"Hewson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Syme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Bruscino\u2010Raiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05867.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00328-8"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.99.132"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2005.tb00384.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","unstructured":"MiglioratiCA SiegelMA EltingLS.Bisphosphonate associated osteonecrosis: a long\u2010term complication of bisphosphonate treatment.Lancet Oncol2006;7:508\u2013514.Erratum in:Lancet Oncol2006;7:533.","DOI":"10.1016\/S1470-2045(06)70726-4"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0882-1"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2005.0108"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.03.019"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.06.004"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01143.x"},{"key":"e_1_2_4_15_2","unstructured":"MarxR.Oral and intravenous bisphosphonate induced osteonecrosis of the jaws.Quintessence Publishing 2007."},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.02.004"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01824.x"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0688-1"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.11.014"}],"container-title":["Australian Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1834-7819.2012.01675.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1834-7819.2012.01675.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:47:06Z","timestamp":1697406426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1834-7819.2012.01675.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1834-7819.2012.01675.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1834-7819.2012.01675.x","archive":["Portico"],"relation":{},"ISSN":["0045-0421","1834-7819"],"issn-type":[{"value":"0045-0421","type":"print"},{"value":"1834-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]},"assertion":[{"value":"2012-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}