{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:25:45Z","timestamp":1769268345078,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The accuracy of bacterial culture and PCR for<jats:italic>Salmonella<\/jats:italic>in swine was examined through systematic review of existing primary research in this field. A replicable search was conducted in 10 electronic databases. All steps of the review were conducted by two reviewers: to identify relevant publications, to assess their methodological soundness and reporting, and to extract raw data or reported test accuracy estimates. Meta\u2010analyses and meta\u2010regression were performed: to evaluate pooled estimates of test sensitivity (Se) and specificity (Sp), to identify variables explaining the variation in reported test estimates, and to evaluate the association between these variables and reported test Se and Sp. Twenty\u2010nine studies were included in the review. Unique test evaluations reported in these 29 studies were categorized according to the type of test comparison: culture versus culture (<jats:italic>n<\/jats:italic>\u2003=\u2003134 test evaluations) and PCR versus culture (<jats:italic>n<\/jats:italic>\u2003=\u200321). We identified significant heterogeneity among evaluations for each test category. For culture, more heterogeneity was caused by differences in individual test protocols (52%) than overall differences between studies (16%). Enrichment temperature, study population, agar and enrichment type were significantly associated with variation in culture Se. Furthermore, interaction between enrichment temperature and enrichment type was detected. For PCR, most of the heterogeneity was caused by overall differences between studies (65\u201370%); sample type and study size were associated with variation in reported PCR Se and Sp. The overall methodological soundness and\/or reporting of primary studies included in this review were poor, with variable use of reference standards, and consistent lack of the use or reporting of blinding, randomization and subject (sample) selection criteria. Consequently, the food safety and veterinary public health research community should formally consider ways for standardizing the conduct and reporting of this type of research.<\/jats:p>","DOI":"10.1111\/j.1863-2378.2010.01366.x","type":"journal-article","created":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T00:50:22Z","timestamp":1290041422000},"page":"121-134","source":"Crossref","is-referenced-by-count":18,"title":["Examining Heterogeneity in the Diagnostic Accuracy of Culture and PCR for<i>Salmonella<\/i>spp. in Swine: A Systematic Review\/Meta\u2010Regression Approach"],"prefix":"10.1111","volume":"57","author":[{"given":"W.","family":"Wilkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Raji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sargeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Waldner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta11360"},{"key":"e_1_2_7_3_1","unstructured":"Anonymous 2007:ISO 6579:2002\/Amd.1:2007(E): Microbiology of food and animal feeding stuffs \u2013 horizontal method for the detection of Salmonella spp. AMENDMENT 1: Annex D: Detection of Salmonella spp. in animal faeces and in environmental samples from the primary production stage.International Standards Organization. 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