{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:44:39Z","timestamp":1773287079850,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tularemia is a zoonotic disease caused by<jats:italic>Francisella tularensis<\/jats:italic>. The distribution of the pathogen in Japan has not been studied well. In this study, seroprevalence of tularemia among wild black bears and hares in Japan was determined. Blood samples collected from 431 Japanese black bears (<jats:italic>Ursus thibetanus japonicus<\/jats:italic>) and 293 Japanese hares (<jats:italic>Lepus brachurus<\/jats:italic>) between 1998 and 2009 were examined for antibodies against<jats:italic>F. tularensis<\/jats:italic>by micro\u2010agglutination test (MA) or enzyme\u2010linked immunosorbent assay. By subsequent confirmatory tests using western blot (WB) and indirect immunofluorescence assay (IFA), eight sera from Japanese black bears were definitely shown to be seropositive. All of these eight bears were residents of the northeastern part of main\u2010island of Japan, where human tularemia had been reported. On the other hand, no seropositive Japanese hares were found. These results suggest that Japanese black bears can serve as sentinel for tularemia surveillance and may help understand the distribution of<jats:italic>F. tularensis<\/jats:italic>throughout the country. This is the first report on detection of antibody to<jats:italic>F. tularensis<\/jats:italic>in black bears of Japan.<\/jats:p>","DOI":"10.1111\/j.1863-2378.2011.01422.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T17:08:47Z","timestamp":1311700127000},"page":"89-95","source":"Crossref","is-referenced-by-count":10,"title":["Seroprevalence of Tularemia in Wild Bears and Hares in Japan"],"prefix":"10.1111","volume":"59","author":[{"given":"A.","family":"Hotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tanabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Uda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.2005.00898.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1206.05879"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-16.3.423"},{"key":"e_1_2_7_5_1","first-page":"603","article-title":"Public health consequences of a false\u2010positive laboratory test result for Brucella \u2013 Florida, Georgia, and Michigan, 2005","volume":"57","author":"CDC","year":"2008","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.17.3.1134"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.270-273.2001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.631-646.2002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1926.02670440003002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-39.4.751"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7883\/yoken.JJID.2006.46","article-title":"Development of a real\u2010time PCR assay for detection and quantification of Francisella tularensis","volume":"59","author":"Fujita O.","year":"2006","journal-title":"Jpn. J. Infect. Dis."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00036.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(02)00213-2"},{"key":"e_1_2_7_14_1","first-page":"25","article-title":"The ecology of tularemia","volume":"18","author":"Hopla C. E.","year":"1974","journal-title":"Adv. Vet. Sci. Comp. Med."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00057-06"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.06.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470344880.ch18"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-24.3.422"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01643750"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1996.tb00234.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.001629"},{"key":"e_1_2_7_22_1","first-page":"1008","article-title":"Comparison of enzyme\u2010linked immunosorbent assay, Western blotting, microagglutination, indirect immunofluorescence assay, and flow cytometry for serological diagnosis of tularemia","volume":"11","author":"Porsch\u2010Ozcurumez M.","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.10.2372-2374.1990"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-33.4.733"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1996.tb00237.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5686\/jjzwm.3.17","article-title":"Ecological and physiological studies of the Japanese black bear, Ursus thibetanus japonicus","volume":"3","author":"Tsubota T.","year":"1998","journal-title":"Jpn. J. Zoo Wildl. Med."},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.7883\/yoken.JJID.2007.355","article-title":"Comparison of whole genome amplification methods for detecting pathogenic bacterial genomic DNA using microarray","volume":"60","author":"Uda A.","year":"2007","journal-title":"Jpn. J. Infect. Dis."},{"key":"e_1_2_7_28_1","first-page":"257","article-title":"Possible expansion of Japanese black bear distribution in the southern part of the Abukuma Mts. (Ibaraki, Fukushima and Tochigi Prefectures), central part of Japan","volume":"49","author":"Yamazaki K.","year":"2009","journal-title":"Mammalian Science"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1863-2378.2011.01422.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1863-2378.2011.01422.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T03:23:01Z","timestamp":1712632981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1863-2378.2011.01422.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,25]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1863-2378.2011.01422.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1863-2378.2011.01422.x","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"value":"1863-1959","type":"print"},{"value":"1863-2378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,25]]}}}