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Hyg.<\/jats:italic>, 73, 1979, 618; <jats:italic>MMWR Morb. Mortal. Wkly Rep.<\/jats:italic>, 49, 2000, 905). The introduction of RVFV would cause critical public health, agricultural and economic damage. Despite the clear need for an efficacious vaccine, there are no United States (US) Food and Drug Administration or US Department of Agriculture approved vaccines against RVFV. To address this need, a virus\u2010like particle (VLP)\u2010based vaccine candidate was developed. First, a non\u2010replicating chimeric RVF VLP vaccine candidate was generated that protected mice and rats against a lethal RVFV challenge. This was followed by the development and optimization of conditions for production of RVF VLPs in insect and mammalian cells. Immunological studies demonstrated that VLP\u2010based vaccine candidates elicit both humoral and cellular immune responses. Subsequent challenge studies using a lethal wild\u2010type RVFV strain under high\u2010containment conditions showed that RVF VLP vaccine candidates can completely protect mice and rats.<\/jats:p>","DOI":"10.1111\/j.1863-2378.2012.01478.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T12:04:00Z","timestamp":1347019440000},"page":"142-150","source":"Crossref","is-referenced-by-count":6,"title":["Virus\u2010Like Particle\u2010Based Countermeasures Against Rift Valley Fever Virus"],"prefix":"10.1111","volume":"59","author":[{"given":"R.","family":"Koukuntla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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