{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:14:41Z","timestamp":1793060081139,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T00:00:00Z","timestamp":1171411200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> With advent of reverse\u2010transcription (RT)\/polymerase chain reaction (PCR) for detection of the hepatitis E viral genome, we carried out retrospective examinations.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Serum samples collected from 68 patients diagnosed as viral hepatitis with unknown etiology were tested for viral markers of hepatitis virus.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Two of them were found positive for hepatitis E viral RNA. While the clinical course of one patient (patient 1) was typical as acute hepatitis E, another patient (patient 2) was persistently infected with HEV. Patient 2 was infected with the virus via blood transfusion during chemotherapy against T\u2010cell lymphoma. The entire viral genome from the donor was identical with that from the serum of patient 2 obtained on day 170 after the transfusion of the implicated red blood cell (RBC) product, confirming the transmission of HEV by transfusion. The patient remained negative for anti\u2010HEV antibodies for the follow\u2010up period of six months, probably due to immune suppression by lymphoma and chemotherapy.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We report here an unusual case of long\u2010term HEV infection in a patient with T\u2010cell lymphoma. Persistent infection with HEV was probably due to the absence of anti\u2010HEV antibodies, which was caused by lymphoma and chemotherapy.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00024.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T13:15:26Z","timestamp":1284556526000},"page":"113-120","source":"Crossref","is-referenced-by-count":184,"title":["Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T\u2010cell lymphoma"],"prefix":"10.1111","volume":"37","author":[{"given":"Akinori","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko K.","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torahiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumichi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Mishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03300.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20215"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14025-1"},{"key":"e_1_2_6_5_2","first-page":"3051","volume-title":"Fields Virology","author":"Purcell RH","year":"2001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19242-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063231"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01840889"},{"key":"e_1_2_6_9_2","first-page":"406","article-title":"The neighbor\u2010joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou N","year":"1987","journal-title":"Mol Biol Evol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200011)62:3<327::AID-JMV4>3.0.CO;2-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2031"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18918-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19052-0"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2007.00024.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2007.00024.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:13:31Z","timestamp":1696968811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2007.00024.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1872-034X.2007.00024.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2007.00024.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}